3EKV
Crystal structure of the wild type HIV-1 protease with the inhibitor, Amprenavir
Summary for 3EKV
Entry DOI | 10.2210/pdb3ekv/pdb |
Related | 3EKP 3EKQ 3EKT 3EKW 3EKX 3EKY 3EL0 3EL1 3EL4 3EL5 |
Descriptor | Protease, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER, ACETATE ION, ... (4 entities in total) |
Functional Keywords | protease inhibitor, drug resistance, amprenavir, hiv protease, aids, protease, hydrolase |
Biological source | HIV-1 M:B_ARV2/SF2 (HIV-1) |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369 |
Total number of polymer chains | 2 |
Total formula weight | 22373.38 |
Authors | Schiffer, C.A.,Nalam, M.N.L. (deposition date: 2008-09-19, release date: 2009-09-01, Last modification date: 2023-08-30) |
Primary citation | King, N.M.,Prabu-Jeyabalan, M.,Bandaranayake, R.M.,Nalam, M.N.,Nalivaika, E.A.,Ozen, A.,Yilmaz, N.K.,Schiffer, C.A. Extreme Entropy-Enthalpy Compensation in a Drug-Resistant Variant of HIV-1 Protease. Acs Chem.Biol., 7:1536-1546, 2012 Cited by PubMed: 22712830DOI: 10.1021/cb300191k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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