3EKV
Crystal structure of the wild type HIV-1 protease with the inhibitor, Amprenavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Protease | polymer | 99 | 10815.8 | 2 | UniProt (P03369) Pfam (PF00077) | HIV-1 M:B_ARV2/SF2 (HIV-1) | Retropepsin, PR |
| 2 | C (A) | {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER | non-polymer | 505.6 | 1 | Chemie (478) PubChem (22868212) PubChem (44342222) PubChem (68164690) PubChem (441385) PubChem (59964701) PubChem (124638074) PubChem (10885665) PubChem (11168069) PubChem (68088939) PubChem (68336859) PubChem (2177) PubChem (65016) PubChem (92209736) PubChem (6540587) PubChem (9898472) PubChem (141823677) | |||
| 3 | D, E, F, G (A) | ACETATE ION | non-polymer | 59.0 | 4 | Chemie (ACT) PubChem (175) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 124 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03369)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 497 | engineered mutation |
| Ile 64 | Val 554 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21631.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 741.8 | |
| All* | Total formula weight | 22373.4 |
