3EKP
Crystal Structure of the inhibitor Amprenavir (APV) in complex with a multi-drug resistant HIV-1 protease variant (L10I/G48V/I54V/V64I/V82A)Refer: FLAP+ in citation
Summary for 3EKP
Entry DOI | 10.2210/pdb3ekp/pdb |
Descriptor | Protease, PHOSPHATE ION, ACETATE ION, ... (5 entities in total) |
Functional Keywords | hiv-1, protease, multi-drug resistance, amprenavir, aids, hydrolase |
Biological source | HIV-1 M:B_ARV2/SF2 (HIV-1) |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369 |
Total number of polymer chains | 4 |
Total formula weight | 45362.82 |
Authors | Prabu-Jayabalan, M.,King, N.M.,Bandaranayake, R.M. (deposition date: 2008-09-19, release date: 2009-09-01, Last modification date: 2024-02-21) |
Primary citation | King, N.M.,Prabu-Jeyabalan, M.,Bandaranayake, R.M.,Nalam, M.N.,Nalivaika, E.A.,Ozen, A.,Yilmaz, N.K.,Schiffer, C.A. Extreme Entropy-Enthalpy Compensation in a Drug-Resistant Variant of HIV-1 Protease. Acs Chem.Biol., 7:1536-1546, 2012 Cited by PubMed: 22712830DOI: 10.1021/cb300191k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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