Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| C | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| D | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 A 501 |
| Chain | Residue |
| A | ARG14 |
| A | GLY16 |
| A | GLY17 |
| A | PRO63 |
| A | HOH665 |
| D | MET46 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 601 |
| Chain | Residue |
| A | GLY68 |
| A | THR12 |
| A | GLU65 |
| A | CYS67 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 602 |
| Chain | Residue |
| A | ALA71 |
| A | ILE72 |
| A | GLN92 |
| C | ARG8 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT A 603 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE 478 B 200 |
| Chain | Residue |
| A | ASP25 |
| A | GLY27 |
| A | ALA28 |
| A | ASP30 |
| A | VAL32 |
| A | GLY49 |
| A | ILE50 |
| A | ILE84 |
| B | ASP25 |
| B | GLY27 |
| B | ALA28 |
| B | ASP30 |
| B | VAL32 |
| B | VAL48 |
| B | GLY49 |
| B | ILE50 |
| B | PRO81 |
| B | HOH666 |
| B | HOH670 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 B 502 |
| Chain | Residue |
| B | LYS7 |
| B | ARG8 |
| B | HOH658 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 B 503 |
| Chain | Residue |
| B | ARG14 |
| B | GLY16 |
| B | GLY17 |
| B | PRO63 |
| B | HOH620 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 B 505 |
| Chain | Residue |
| B | THR12 |
| B | ILE13 |
| B | ARG14 |
| B | LEU19 |
| B | GLU65 |
| B | ILE66 |
| B | CYS67 |
| B | GLY68 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT B 604 |
| Chain | Residue |
| B | THR91 |
| B | GLN92 |
| B | HOH628 |
| D | GLU34 |
| D | ALA82 |
| D | ASN83 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT B 605 |
| Chain | Residue |
| B | ALA71 |
| B | ILE72 |
| B | GLN92 |
| B | HOH643 |
| D | ARG8 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT B 606 |
| Chain | Residue |
| B | GLY73 |
| B | THR74 |
| B | ASN88 |
| site_id | BC3 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 478 C 200 |
| Chain | Residue |
| C | ASP25 |
| C | GLY27 |
| C | ALA28 |
| C | ASP30 |
| C | VAL32 |
| C | VAL48 |
| C | GLY49 |
| C | ILE50 |
| C | PRO81 |
| C | ILE84 |
| C | HOH683 |
| D | ASP25 |
| D | GLY27 |
| D | ALA28 |
| D | ASP30 |
| D | VAL32 |
| D | VAL48 |
| D | GLY49 |
| D | ILE50 |
| D | ILE84 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT C 601 |
| Chain | Residue |
| C | THR12 |
| C | ILE13 |
| C | ARG14 |
| C | GLU65 |
| C | CYS67 |
| C | GLY68 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT C 603 |
| Chain | Residue |
| A | THR91 |
| A | GLN92 |
| C | GLU34 |
| C | ALA82 |
| C | ASN83 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT C 604 |
| Chain | Residue |
| C | PRO81 |
| A | GLY68 |
| A | HIS69 |
| A | LYS70 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT C 605 |
| Chain | Residue |
| C | LYS7 |
| C | ARG8 |
| C | HOH624 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT D 602 |
| Chain | Residue |
| D | THR12 |
| D | GLU65 |
| D | ILE66 |
| D | CYS67 |
| D | GLY68 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT D 606 |
| Chain | Residue |
| D | ILE72 |
| D | GLY73 |
| D | THR74 |
| D | ASN88 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL |
| Chain | Residue | Details |
| A | ALA22-LEU33 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 276 |
| Details | Domain: {"description":"Peptidase A2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00275","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | Region: {"description":"Dimerization of protease","evidences":[{"source":"UniProtKB","id":"P04585","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Active site: {"description":"For protease activity; shared with dimeric partner","evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| A | ASP25 | |
| A | THR26 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| B | ASP25 | |
| B | THR26 | |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| C | ASP25 | |
| C | THR26 | |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| D | ASP25 | |
| D | THR26 | |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| A | ASP25 | |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| B | ASP25 | |
| site_id | CSA7 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| C | ASP25 | |
| site_id | CSA8 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| D | ASP25 | |
3EKP
