3EE0
Crystal Structure of the W215A/E217A Mutant of Human Thrombin (space group P2(1)2(1)2(1))
Summary for 3EE0
Entry DOI | 10.2210/pdb3ee0/pdb |
Related | 1TQ0 3EDX |
Descriptor | Thrombin light chain, Thrombin heavy chain (2 entities in total) |
Functional Keywords | serine protease, acute phase, blood coagulation, calcium, cleavage on pair of basic residues, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, pharmaceutical, polymorphism, protease, secreted, zymogen |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 |
Total number of polymer chains | 2 |
Total formula weight | 33703.59 |
Authors | Gandhi, P.S.,Page, M.J.,Chen, Z.,Bush-Pelc, L.,Di Cera, E. (deposition date: 2008-09-03, release date: 2009-07-07, Last modification date: 2023-08-30) |
Primary citation | Gandhi, P.S.,Page, M.J.,Chen, Z.,Bush-Pelc, L.,Di Cera, E. Molecular Basis for the Kinetic Differences of the W215A/E217A Mutant of Human and Murine Thrombin To be Published, |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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