3DO4

Crystal structure of transthyretin variant T60A at acidic pH

Summary for 3DO4

• Entry DOI: 10.2210/pdb3do4/pdb
• Related: 1F41 2G4E 3DJR 3DJS 3DJT
• Descriptor: Transthyretin, ACETATE ION (3 entities in total)
• Functional Keywords: ttr, amyloid fibrils, point mutation, transport protein, retinol-binding, thyroid hormone, amyloid, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hormone, polymorphism, polyneuropathy, secreted, vitamin a
• Biological source: HOMO SAPIENS (human)
• Cellular location: Secreted: P02766
• Total number of polymer chains: 8
• Total formula weight: 110273.89

Authors

Cendron, L.,Zanotti, G.,Folli, C.,Berni, R. (deposition date: 2008-07-03, release date: 2009-07-14, Last modification date: 2023-11-01)

• Primary citation: Cendron, L.,Trovato, A.,Seno, F.,Folli, C.,Alfieri, B.,Zanotti, G.,Berni, R.; Amyloidogenic potential of transthyretin variants: Insights from structural and computational analyses; To be Published,

Experimental method

X-RAY DIFFRACTION (2.4 Å)