3DO4

Crystal structure of transthyretin variant T60A at acidic pH

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Transthyretin	polymer	127	13747.3	8	UniProt (P02766) Pfam (PF00576)	HOMO SAPIENS (human)	Prealbumin, TBPA, TTR, ATTR
2	I, J, K, L, M (A, B, G, H)	ACETATE ION	non-polymer		59.0	5	Chemie (ACT)
3	N, O, P, Q, R... (A, B, C, D, E...)	water	water		18.0	131	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H: 1 - 127 (UniProt: P02766)

PDB	External Database	Details
Ala 60	Thr 80	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	109978.7
Non-Polymers*	Number of molecules	5
	Total formula weight	295.2
All*	Total formula weight	110273.9

*Water molecules are not included.