3DO4

Crystal structure of transthyretin variant T60A at acidic pH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001523	biological_process	retinoid metabolic process
A	0003105	biological_process	negative regulation of glomerular filtration
A	0005179	molecular_function	hormone activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0006144	biological_process	purine nucleobase metabolic process
A	0007603	biological_process	phototransduction, visible light
A	0032991	cellular_component	protein-containing complex
A	0035578	cellular_component	azurophil granule lumen
A	0042562	molecular_function	hormone binding
A	0042802	molecular_function	identical protein binding
A	0044877	molecular_function	protein-containing complex binding
A	0070062	cellular_component	extracellular exosome
A	0140313	molecular_function	molecular sequestering activity
B	0001523	biological_process	retinoid metabolic process
B	0003105	biological_process	negative regulation of glomerular filtration
B	0005179	molecular_function	hormone activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0006144	biological_process	purine nucleobase metabolic process
B	0007603	biological_process	phototransduction, visible light
B	0032991	cellular_component	protein-containing complex
B	0035578	cellular_component	azurophil granule lumen
B	0042562	molecular_function	hormone binding
B	0042802	molecular_function	identical protein binding
B	0044877	molecular_function	protein-containing complex binding
B	0070062	cellular_component	extracellular exosome
B	0140313	molecular_function	molecular sequestering activity
C	0001523	biological_process	retinoid metabolic process
C	0003105	biological_process	negative regulation of glomerular filtration
C	0005179	molecular_function	hormone activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0006144	biological_process	purine nucleobase metabolic process
C	0007603	biological_process	phototransduction, visible light
C	0032991	cellular_component	protein-containing complex
C	0035578	cellular_component	azurophil granule lumen
C	0042562	molecular_function	hormone binding
C	0042802	molecular_function	identical protein binding
C	0044877	molecular_function	protein-containing complex binding
C	0070062	cellular_component	extracellular exosome
C	0140313	molecular_function	molecular sequestering activity
D	0001523	biological_process	retinoid metabolic process
D	0003105	biological_process	negative regulation of glomerular filtration
D	0005179	molecular_function	hormone activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005737	cellular_component	cytoplasm
D	0006144	biological_process	purine nucleobase metabolic process
D	0007603	biological_process	phototransduction, visible light
D	0032991	cellular_component	protein-containing complex
D	0035578	cellular_component	azurophil granule lumen
D	0042562	molecular_function	hormone binding
D	0042802	molecular_function	identical protein binding
D	0044877	molecular_function	protein-containing complex binding
D	0070062	cellular_component	extracellular exosome
D	0140313	molecular_function	molecular sequestering activity
E	0001523	biological_process	retinoid metabolic process
E	0003105	biological_process	negative regulation of glomerular filtration
E	0005179	molecular_function	hormone activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005737	cellular_component	cytoplasm
E	0006144	biological_process	purine nucleobase metabolic process
E	0007603	biological_process	phototransduction, visible light
E	0032991	cellular_component	protein-containing complex
E	0035578	cellular_component	azurophil granule lumen
E	0042562	molecular_function	hormone binding
E	0042802	molecular_function	identical protein binding
E	0044877	molecular_function	protein-containing complex binding
E	0070062	cellular_component	extracellular exosome
E	0140313	molecular_function	molecular sequestering activity
F	0001523	biological_process	retinoid metabolic process
F	0003105	biological_process	negative regulation of glomerular filtration
F	0005179	molecular_function	hormone activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005737	cellular_component	cytoplasm
F	0006144	biological_process	purine nucleobase metabolic process
F	0007603	biological_process	phototransduction, visible light
F	0032991	cellular_component	protein-containing complex
F	0035578	cellular_component	azurophil granule lumen
F	0042562	molecular_function	hormone binding
F	0042802	molecular_function	identical protein binding
F	0044877	molecular_function	protein-containing complex binding
F	0070062	cellular_component	extracellular exosome
F	0140313	molecular_function	molecular sequestering activity
G	0001523	biological_process	retinoid metabolic process
G	0003105	biological_process	negative regulation of glomerular filtration
G	0005179	molecular_function	hormone activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005737	cellular_component	cytoplasm
G	0006144	biological_process	purine nucleobase metabolic process
G	0007603	biological_process	phototransduction, visible light
G	0032991	cellular_component	protein-containing complex
G	0035578	cellular_component	azurophil granule lumen
G	0042562	molecular_function	hormone binding
G	0042802	molecular_function	identical protein binding
G	0044877	molecular_function	protein-containing complex binding
G	0070062	cellular_component	extracellular exosome
G	0140313	molecular_function	molecular sequestering activity
H	0001523	biological_process	retinoid metabolic process
H	0003105	biological_process	negative regulation of glomerular filtration
H	0005179	molecular_function	hormone activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005737	cellular_component	cytoplasm
H	0006144	biological_process	purine nucleobase metabolic process
H	0007603	biological_process	phototransduction, visible light
H	0032991	cellular_component	protein-containing complex
H	0035578	cellular_component	azurophil granule lumen
H	0042562	molecular_function	hormone binding
H	0042802	molecular_function	identical protein binding
H	0044877	molecular_function	protein-containing complex binding
H	0070062	cellular_component	extracellular exosome
H	0140313	molecular_function	molecular sequestering activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT H 128

Chain	Residue
G	TRP41
G	GLU92
H	LYS70
H	HIS90
H	GLU92

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT A 128

Chain	Residue
A	TYR116
A	SER117
A	LEU110
A	LEU111
A	SER112
A	SER115

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT G 128

Chain	Residue
G	LYS70
G	HIS90
G	GLU92

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT A 129

Chain	Residue
A	LYS70
A	GLU72
A	HIS90
A	GLU92
B	TRP41
B	LYS70

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT B 128

Chain	Residue
A	TRP41
B	LYS70
B	HIS90
B	GLU92

---

Functional Information from PROSITE/UniProt

site_id	PS00768
Number of Residues	16
Details	TRANSTHYRETIN_1 Transthyretin signature 1. KVLDavrGsPAinVaV

Chain	Residue	Details
A	LYS15-VAL30

---

site_id	PS00769
Number of Residues	13
Details	TRANSTHYRETIN_2 Transthyretin signature 2. YTIAalLSPYSYS

Chain	Residue	Details
A	TYR105-SER117

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11418763","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ICT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Modified residue: {"description":"Sulfocysteine","evidences":[{"source":"PubMed","id":"17175208","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2H4E","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Modified residue: {"description":"4-carboxyglutamate; in a patient with Moyamoya disease","evidences":[{"source":"PubMed","id":"18221012","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P02767","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19167329","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---