3D85

Crystal structure of IL-23 in complex with neutralizing FAB

Summary for 3D85
Related1F45 3D87
DescriptorFAB of antibody 7G10, light chain, FAB of antibody 7G10, heavy chain, Interleukin-23 subunit p19, ... (7 entities in total)
Functional Keywordsinterleukin-23, fab, immune system-cytokine complex, immune system/cytokine
Biological sourceHomo sapiens (human)
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Cellular locationSecreted: Q9NPF7 P29460
Total number of polymer chains4
Total formula weight102027.23
Authors
Beyer, B.M.,Ingram, R.,Ramanathan, L.,Reichert, P.,Le, H.,Madison, V. (deposition date: 2008-05-22, release date: 2008-09-02, Last modification date: 2011-07-13)
Primary citationBeyer, B.M.,Ingram, R.,Le, H.V.,Madison, V.,Orth, P.,Ramanathan, L.,Reichert, P.
Crystal structures of the pro-inflammatory cytokine interleukin-23 and its complex with a high-affinity neutralizing antibody
J.Mol.Biol., 382:942-955, 2008
PubMed: 18708069
DOI: 110.1016/j.jmb.2008.08.001
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation
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PDB entries from 2021-06-09