3D85
Crystal structure of IL-23 in complex with neutralizing FAB
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | FAB of antibody 7G10, light chain | polymer | 214 | 23455.0 | 1 | Homo sapiens (human) | ||
2 | B | FAB of antibody 7G10, heavy chain | polymer | 223 | 23843.7 | 1 | Pfam (PF07654) UniProt (by SIFTS) (P01857) In PDB | Homo sapiens (human) | |
3 | C | Interleukin-23 subunit p19 | polymer | 178 | 19669.1 | 1 | UniProt (Q9NPF7) Pfam (PF16649) In PDB | Homo sapiens (human) | Interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23p19 |
4 | D | Interleukin-12 subunit p40 | polymer | 306 | 34754.0 | 1 | UniProt (P29460) Pfam (PF10420) In PDB | Homo sapiens (human) | IL-12B; IL-12 subunit p40; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; NK cell stimulatory factor chain 2; NKSF2 |
5 | A | IMIDAZOLE | non-polymer | 69.1 | 1 | Chemie (IMD) | |||
6 | A, B | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 2 | Chemie (MPD) | |||
7 | water | water | 18.0 | 906 | Chemie (HOH) |
Sequence modifications
C: 1 - 170 (UniProt: Q9NPF7)
D: 1 - 306 (UniProt: P29460)
PDB | External Database | Details |
---|---|---|
Gly 171 | - | expression tag |
Ser 172 | - | expression tag |
His 173 | - | expression tag |
His 174 | - | expression tag |
His 175 | - | expression tag |
His 176 | - | expression tag |
His 177 | - | expression tag |
His 178 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gln 200 | Asn 222 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 101721.8 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 305.4 | |
All* | Total formula weight | 102027.2 |