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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

3D85

Crystal structure of IL-23 in complex with neutralizing FAB

Functional Information from GO Data
ChainGOidnamespacecontents
C0001916biological_processpositive regulation of T cell mediated cytotoxicity
C0002230biological_processpositive regulation of defense response to virus by host
C0002376biological_processimmune system process
C0002827biological_processpositive regulation of T-helper 1 type immune response
C0005125molecular_functioncytokine activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005788cellular_componentendoplasmic reticulum lumen
C0006954biological_processinflammatory response
C0006955biological_processimmune response
C0007259biological_processcell surface receptor signaling pathway via JAK-STAT
C0010468biological_processregulation of gene expression
C0010557biological_processpositive regulation of macromolecule biosynthetic process
C0032693biological_processnegative regulation of interleukin-10 production
C0032725biological_processpositive regulation of granulocyte macrophage colony-stimulating factor production
C0032729biological_processpositive regulation of type II interferon production
C0032733biological_processpositive regulation of interleukin-10 production
C0032735biological_processpositive regulation of interleukin-12 production
C0032740biological_processpositive regulation of interleukin-17 production
C0032760biological_processpositive regulation of tumor necrosis factor production
C0032816biological_processpositive regulation of natural killer cell activation
C0032819biological_processpositive regulation of natural killer cell proliferation
C0034105biological_processpositive regulation of tissue remodeling
C0038155biological_processinterleukin-23-mediated signaling pathway
C0042102biological_processpositive regulation of T cell proliferation
C0042104biological_processpositive regulation of activated T cell proliferation
C0043382biological_processpositive regulation of memory T cell differentiation
C0045087biological_processinnate immune response
C0045519molecular_functioninterleukin-23 receptor binding
C0045672biological_processpositive regulation of osteoclast differentiation
C0046635biological_processpositive regulation of alpha-beta T cell activation
C0048771biological_processtissue remodeling
C0050729biological_processpositive regulation of inflammatory response
C0050829biological_processdefense response to Gram-negative bacterium
C0051135biological_processpositive regulation of NK T cell activation
C0051142biological_processpositive regulation of NK T cell proliferation
C0051607biological_processdefense response to virus
C0070743cellular_componentinterleukin-23 complex
C0080090biological_processregulation of primary metabolic process
C0090023biological_processpositive regulation of neutrophil chemotaxis
C0097696biological_processcell surface receptor signaling pathway via STAT
C1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
C1902107biological_processpositive regulation of leukocyte differentiation
C2000318biological_processpositive regulation of T-helper 17 type immune response
C2000330biological_processpositive regulation of T-helper 17 cell lineage commitment
D0001817biological_processregulation of cytokine production
D0001912biological_processpositive regulation of leukocyte mediated cytotoxicity
D0001916biological_processpositive regulation of T cell mediated cytotoxicity
D0002230biological_processpositive regulation of defense response to virus by host
D0002323biological_processnatural killer cell activation involved in immune response
D0002708biological_processpositive regulation of lymphocyte mediated immunity
D0002827biological_processpositive regulation of T-helper 1 type immune response
D0002860biological_processpositive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
D0004896molecular_functioncytokine receptor activity
D0005125molecular_functioncytokine activity
D0005126molecular_functioncytokine receptor binding
D0005143molecular_functioninterleukin-12 receptor binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005737cellular_componentcytoplasm
D0005788cellular_componentendoplasmic reticulum lumen
D0005829cellular_componentcytosol
D0007259biological_processcell surface receptor signaling pathway via JAK-STAT
D0008083molecular_functiongrowth factor activity
D0009986cellular_componentcell surface
D0010224biological_processresponse to UV-B
D0016020cellular_componentmembrane
D0016477biological_processcell migration
D0030101biological_processnatural killer cell activation
D0031904cellular_componentendosome lumen
D0031906cellular_componentlate endosome lumen
D0032693biological_processnegative regulation of interleukin-10 production
D0032700biological_processnegative regulation of interleukin-17 production
D0032725biological_processpositive regulation of granulocyte macrophage colony-stimulating factor production
D0032729biological_processpositive regulation of type II interferon production
D0032733biological_processpositive regulation of interleukin-10 production
D0032735biological_processpositive regulation of interleukin-12 production
D0032740biological_processpositive regulation of interleukin-17 production
D0032760biological_processpositive regulation of tumor necrosis factor production
D0032816biological_processpositive regulation of natural killer cell activation
D0032819biological_processpositive regulation of natural killer cell proliferation
D0032946biological_processpositive regulation of mononuclear cell proliferation
D0034105biological_processpositive regulation of tissue remodeling
D0034393biological_processpositive regulation of smooth muscle cell apoptotic process
D0035722biological_processinterleukin-12-mediated signaling pathway
D0038155biological_processinterleukin-23-mediated signaling pathway
D0042088biological_processT-helper 1 type immune response
D0042093biological_processT-helper cell differentiation
D0042102biological_processpositive regulation of T cell proliferation
D0042104biological_processpositive regulation of activated T cell proliferation
D0042110biological_processT cell activation
D0042164molecular_functioninterleukin-12 alpha subunit binding
D0042802molecular_functionidentical protein binding
D0043382biological_processpositive regulation of memory T cell differentiation
D0043514cellular_componentinterleukin-12 complex
D0044877molecular_functionprotein-containing complex binding
D0045519molecular_functioninterleukin-23 receptor binding
D0045672biological_processpositive regulation of osteoclast differentiation
D0045785biological_processpositive regulation of cell adhesion
D0046982molecular_functionprotein heterodimerization activity
D0048599biological_processoocyte development
D0048662biological_processnegative regulation of smooth muscle cell proliferation
D0050671biological_processpositive regulation of lymphocyte proliferation
D0050709biological_processnegative regulation of protein secretion
D0050727biological_processregulation of inflammatory response
D0050729biological_processpositive regulation of inflammatory response
D0050829biological_processdefense response to Gram-negative bacterium
D0051135biological_processpositive regulation of NK T cell activation
D0051142biological_processpositive regulation of NK T cell proliferation
D0070743cellular_componentinterleukin-23 complex
D1900747biological_processnegative regulation of vascular endothelial growth factor signaling pathway
D1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
D1903588biological_processnegative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
D2000318biological_processpositive regulation of T-helper 17 type immune response
D2000330biological_processpositive regulation of T-helper 17 cell lineage commitment
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MPD B 501
ChainResidue
BTHR30
BSER31
BTYR54
CHIS106
site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MPD A 502
ChainResidue
AGLN155
ALEU181
AHIS189
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH
ChainResidueDetails
BTYR196-HIS202
ATYR192-HIS198
site_idPS01354
Number of Residues43
DetailsHEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. IkPDPPknLqlkplknsrq.VevsWeyPdTWstphsyFsLtFcV
ChainResidueDetails
DILE211-VAL253
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues83
DetailsDomain: {"description":"Ig-like C2-type"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10899108","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsGlycosylation: {"description":"C-linked (Man) tryptophan","featureId":"CAR_000187","evidences":[{"source":"PubMed","id":"10207176","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

245663

PDB entries from 2025-12-03

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