3C6M

Crystal structure of human spermine synthase in complex with spermine and 5-methylthioadenosine

Summary for 3C6M

Entry DOI	10.2210/pdb3c6m/pdb
Related	3C6K
Descriptor	Spermine synthase, SPERMINE, 5'-DEOXY-5'-METHYLTHIOADENOSINE, ... (4 entities in total)
Functional Keywords	spermidine aminopropyltransferase, spmsy, structural genomics, structural genomics consortium, sgc, phosphoprotein, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	174010.16
Authors	Min, J.,Wu, H.,Zeng, H.,Loppnau, P.,Weigelt, J.,Sundstrom, M.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Pegg, A.E.,Plotnikov, A.N.,Structural Genomics Consortium (SGC) (deposition date: 2008-02-04, release date: 2008-02-19, Last modification date: 2023-08-30)
Primary citation	Wu, H.,Min, J.,Zeng, H.,McCloskey, D.E.,Ikeguchi, Y.,Loppnau, P.,Michael, A.J.,Pegg, A.E.,Plotnikov, A.N. Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism. J.Biol.Chem., 283:16135-16146, 2008 Cited by PubMed: 18367445 DOI: 10.1074/jbc.M710323200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation