3C6M

Crystal structure of human spermine synthase in complex with spermine and 5-methylthioadenosine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Spermine synthase	polymer	381	43002.9	4	UniProt (P52788) Pfam (PF17950) Pfam (PF17284) Pfam (PF01564)	Homo sapiens (human)	Spermidine aminopropyltransferase, SPMSY
2	E, G, I, K (A, B, C, D)	SPERMINE	non-polymer		202.3	4	Chemie (SPM) PubChem (1103)
3	F, H, J, L (A, B, C, D)	5'-DEOXY-5'-METHYLTHIOADENOSINE	non-polymer		297.3	4	Chemie (MTA) PubChem (25322898) PubChem (40467850) PubChem (51397472) PubChem (44264468) PubChem (99302) PubChem (46874793) PubChem (453683) PubChem (98100246) PubChem (51397471) PubChem (57104771) PubChem (58108938) PubChem (58682801) PubChem (59099797) PubChem (91614589) PubChem (149) PubChem (124300729) PubChem (124300795) PubChem (439176) PubChem (688097) PubChem (6541356) PubChem (13101165) PubChem (13101166) PubChem (134694842) PubChem (138107656) PubChem (164077596)
4	M, N, O, P (A, B, C, D)	water	water		18.0	300	Chemie (HOH)

Sequence modifications

A, B, C, D: 5 - 366 (UniProt: P52788)

PDB	External Database	Details
Met -14	-	expression tag
Gly -13	-	expression tag
Ser -12	-	expression tag
Ser -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
Ser -4	-	expression tag
Ser -3	-	expression tag
Gly -2	-	expression tag
Leu -1	-	expression tag
Val 0	-	expression tag
Pro 1	-	expression tag
Arg 2	-	expression tag
Gly 3	-	expression tag
Ser 4	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	172011.5
Non-Polymers*	Number of molecules	8
	Total formula weight	1998.7
All*	Total formula weight	174010.2

*Water molecules are not included.