3C6M

Crystal structure of human spermine synthase in complex with spermine and 5-methylthioadenosine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Spermine synthase	polymer	381	43002.9	4	UniProt (P52788) Pfam (PF17950) Pfam (PF17284) Pfam (PF01564)	Homo sapiens (human)	Spermidine aminopropyltransferase, SPMSY
2	E, G, I, K (A, B, C, D)	SPERMINE	non-polymer		202.3	4	Chemie (SPM)
3	F, H, J, L (A, B, C, D)	5'-DEOXY-5'-METHYLTHIOADENOSINE	non-polymer		297.3	4	Chemie (MTA)
4	M, N, O, P (A, B, C, D)	water	water		18.0	300	Chemie (HOH)

Sequence modifications

A, B, C, D: 5 - 366 (UniProt: P52788)

PDB	External Database	Details
Met -14	-	expression tag
Gly -13	-	expression tag
Ser -12	-	expression tag
Ser -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
Ser -4	-	expression tag
Ser -3	-	expression tag
Gly -2	-	expression tag
Leu -1	-	expression tag
Val 0	-	expression tag
Pro 1	-	expression tag
Arg 2	-	expression tag
Gly 3	-	expression tag
Ser 4	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	172011.5
Non-Polymers*	Number of molecules	8
	Total formula weight	1998.7
All*	Total formula weight	174010.2

*Water molecules are not included.