3C6M
Crystal structure of human spermine synthase in complex with spermine and 5-methylthioadenosine
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005829 | cellular_component | cytosol |
A | 0006555 | biological_process | methionine metabolic process |
A | 0006595 | biological_process | polyamine metabolic process |
A | 0006596 | biological_process | polyamine biosynthetic process |
A | 0006597 | biological_process | spermine biosynthetic process |
A | 0008215 | biological_process | spermine metabolic process |
A | 0016740 | molecular_function | transferase activity |
A | 0016768 | molecular_function | spermine synthase activity |
A | 0070062 | cellular_component | extracellular exosome |
B | 0005829 | cellular_component | cytosol |
B | 0006555 | biological_process | methionine metabolic process |
B | 0006595 | biological_process | polyamine metabolic process |
B | 0006596 | biological_process | polyamine biosynthetic process |
B | 0006597 | biological_process | spermine biosynthetic process |
B | 0008215 | biological_process | spermine metabolic process |
B | 0016740 | molecular_function | transferase activity |
B | 0016768 | molecular_function | spermine synthase activity |
B | 0070062 | cellular_component | extracellular exosome |
C | 0005829 | cellular_component | cytosol |
C | 0006555 | biological_process | methionine metabolic process |
C | 0006595 | biological_process | polyamine metabolic process |
C | 0006596 | biological_process | polyamine biosynthetic process |
C | 0006597 | biological_process | spermine biosynthetic process |
C | 0008215 | biological_process | spermine metabolic process |
C | 0016740 | molecular_function | transferase activity |
C | 0016768 | molecular_function | spermine synthase activity |
C | 0070062 | cellular_component | extracellular exosome |
D | 0005829 | cellular_component | cytosol |
D | 0006555 | biological_process | methionine metabolic process |
D | 0006595 | biological_process | polyamine metabolic process |
D | 0006596 | biological_process | polyamine biosynthetic process |
D | 0006597 | biological_process | spermine biosynthetic process |
D | 0008215 | biological_process | spermine metabolic process |
D | 0016740 | molecular_function | transferase activity |
D | 0016768 | molecular_function | spermine synthase activity |
D | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE SPM A 501 |
Chain | Residue |
A | TRP124 |
A | LEU277 |
A | TYR351 |
A | GLU353 |
A | TRP355 |
A | HOH571 |
A | HOH576 |
A | PRO125 |
A | TYR134 |
A | ASP167 |
A | VAL168 |
A | ASN169 |
A | TYR177 |
A | ASP201 |
A | ASP276 |
site_id | AC2 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE SPM B 501 |
Chain | Residue |
B | ASP167 |
B | VAL168 |
B | ASN169 |
B | TYR177 |
B | ASP201 |
B | ASP276 |
B | LEU277 |
B | GLN315 |
B | TYR351 |
B | GLU353 |
B | TRP355 |
B | MTA401 |
B | HOH524 |
site_id | AC3 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE SPM C 501 |
Chain | Residue |
C | ASP167 |
C | VAL168 |
C | ASN169 |
C | TYR177 |
C | ASP201 |
C | ASP276 |
C | LEU277 |
C | GLN315 |
C | TYR351 |
C | GLU353 |
C | TRP355 |
C | MTA401 |
C | HOH527 |
C | HOH536 |
C | HOH563 |
site_id | AC4 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE SPM D 501 |
Chain | Residue |
D | TRP124 |
D | THR126 |
D | TYR134 |
D | ASP167 |
D | VAL168 |
D | ASN169 |
D | TYR177 |
D | ASP201 |
D | ASP276 |
D | GLN315 |
D | TYR351 |
D | GLU353 |
D | TRP355 |
site_id | AC5 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE MTA A 401 |
Chain | Residue |
A | GLN148 |
A | LEU162 |
A | LEU164 |
A | ASN169 |
A | GLY198 |
A | GLY199 |
A | GLY200 |
A | ASP201 |
A | VAL219 |
A | GLU220 |
A | ILE221 |
A | ASP222 |
A | VAL225 |
A | ASP255 |
A | CYS256 |
A | ASP276 |
A | LEU277 |
A | THR278 |
A | ILE282 |
site_id | AC6 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE MTA B 401 |
Chain | Residue |
B | GLN148 |
B | LEU162 |
B | LEU164 |
B | ASN169 |
B | GLY198 |
B | GLY199 |
B | ASP201 |
B | VAL219 |
B | GLU220 |
B | ILE221 |
B | ASP222 |
B | VAL225 |
B | ASP255 |
B | CYS256 |
B | ASP276 |
B | LEU277 |
B | THR278 |
B | ILE282 |
B | SPM501 |
site_id | AC7 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE MTA C 401 |
Chain | Residue |
C | GLY199 |
C | GLY200 |
C | ASP201 |
C | VAL219 |
C | GLU220 |
C | ILE221 |
C | VAL225 |
C | ASP255 |
C | CYS256 |
C | ASP276 |
C | LEU277 |
C | THR278 |
C | ILE282 |
C | SPM501 |
C | GLN148 |
C | LEU162 |
C | LEU164 |
C | ASN169 |
C | GLY198 |
site_id | AC8 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE MTA D 401 |
Chain | Residue |
D | GLN148 |
D | LEU164 |
D | ASN169 |
D | GLY198 |
D | GLY199 |
D | GLY200 |
D | ASP201 |
D | VAL219 |
D | GLU220 |
D | ILE221 |
D | VAL225 |
D | ASP255 |
D | CYS256 |
D | ASP276 |
D | LEU277 |
D | THR278 |
D | ILE282 |
Functional Information from PROSITE/UniProt
site_id | PS01330 |
Number of Residues | 14 |
Details | PABS_1 Polyamine biosynthesis (PABS) domain signature. VLILGGGdGgiLcE |
Chain | Residue | Details |
A | VAL194-GLU207 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00354, ECO:0000269|PubMed:18367445 |
Chain | Residue | Details |
A | ASP276 | |
B | ASP276 | |
C | ASP276 | |
D | ASP276 |
site_id | SWS_FT_FI2 |
Number of Residues | 28 |
Details | BINDING: BINDING => ECO:0000269|PubMed:18367445 |
Chain | Residue | Details |
A | GLN148 | |
B | ASP201 | |
B | GLU220 | |
B | ASP255 | |
B | TYR351 | |
B | GLU353 | |
C | GLN148 | |
C | TYR177 | |
C | ASP201 | |
C | GLU220 | |
C | ASP255 | |
A | TYR177 | |
C | TYR351 | |
C | GLU353 | |
D | GLN148 | |
D | TYR177 | |
D | ASP201 | |
D | GLU220 | |
D | ASP255 | |
D | TYR351 | |
D | GLU353 | |
A | ASP201 | |
A | GLU220 | |
A | ASP255 | |
A | TYR351 | |
A | GLU353 | |
B | GLN148 | |
B | TYR177 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER57 | |
B | SER57 | |
C | SER57 | |
D | SER57 |