4Q4S
tRNA-Guanine Transglycosylase (TGT) in Complex with 6-Amino-2-[(thiophen-2-ylmethyl)amino]-1H,7H,8H-imidazo[4,5-g]quinazolin-8-one
Replaces: 3C2ZSummary for 4Q4S
Entry DOI | 10.2210/pdb4q4s/pdb |
Related | 1P0D 4Q4M 4Q4O 4Q4P 4Q4Q 4Q4R |
Descriptor | Queuine tRNA-ribosyltransferase, ZINC ION, GLYCEROL, ... (5 entities in total) |
Functional Keywords | transferase, guanine exchange enzyme, preq1, trna, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Zymomonas mobilis subsp. mobilis |
Total number of polymer chains | 1 |
Total formula weight | 43671.84 |
Authors | |
Primary citation | Neeb, M.,Betz, M.,Heine, A.,Barandun, L.J.,Hohn, C.,Diederich, F.,Klebe, G. Beyond Affinity: Enthalpy-Entropy Factorization Unravels Complexity of a Flat Structure-Activity Relationship for Inhibition of a tRNA-Modifying Enzyme. J.Med.Chem., 57:5566-5578, 2014 Cited by PubMed: 24960372DOI: 10.1021/jm5006868 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.249 Å) |
Structure validation
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