3BEF

Crystal structure of thrombin bound to the extracellular fragment of PAR1

Summary for 3BEF

Entry DOI	10.2210/pdb3bef/pdb
Related	1SHH 2GP9 3BEI
Descriptor	Prothrombin, Proteinase-activated receptor 1, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	serine protease, acute phase, blood coagulation, cleavage on pair of basic residues, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, secreted, zymogen, g-protein coupled receptor, membrane, phosphoprotein, receptor, transducer, transmembrane
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	73193.24
Authors	Gandhi, P.S.,Bah, A.,Chen, Z.,Mathews, F.S.,Di Cera, E. (deposition date: 2007-11-17, release date: 2008-01-01, Last modification date: 2023-08-30)
Primary citation	Gandhi, P.S.,Chen, Z.,Mathews, F.S.,Di Cera, E. Structural identification of the pathway of long-range communication in an allosteric enzyme. Proc.Natl.Acad.Sci.Usa, 105:1832-1837, 2008 Cited by PubMed: 18250335 DOI: 10.1073/pnas.0710894105 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation