3ADZ

Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with intermediate PSPP

Summary for 3ADZ

Entry DOI	10.2210/pdb3adz/pdb
Related	2ZCO 2ZCP 2ZCQ 2ZCR 2ZCS 2ZY1 3AE0
Descriptor	Dehydrosqualene synthase, {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	crtm, carotenoid biosynthesis, staphyloxanthin biosynthesis, transferase, head-to-head condensation, intermediate
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	35330.69
Authors	Liu, C.I.,Jeng, W.Y.,Wang, A.H.J.,Oldfield, E. (deposition date: 2010-01-31, release date: 2010-11-24, Last modification date: 2023-11-01)
Primary citation	Lin, F.Y.,Liu, C.I.,Liu, Y.L.,Zhang, Y.,Wang, K.,Jeng, W.Y.,Ko, T.P.,Cao, R.,Wang, A.H.,Oldfield, E. Mechanism of action and inhibition of dehydrosqualene synthase. Proc.Natl.Acad.Sci.USA, 107:21337-21342, 2010 Cited by PubMed: 21098670 DOI: 10.1073/pnas.1010907107 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.89 Å)

Structure validation