3ZUV

Crystal structure of a designed selected Ankyrin Repeat protein in complex with the phosphorylated MAP kinase ERK2

Summary for 3ZUV

Entry DOI	10.2210/pdb3zuv/pdb
Related	1ERK 1GOL 2ERK 2GPH 3ERK 3ZU7 4ERK
Descriptor	MITOGEN-ACTIVATED PROTEIN KINASE 1, DESIGNED ANKYRIN REPEAT PROTEIN, SULFATE ION, ... (4 entities in total)
Functional Keywords	de novo protein-transferase complex, ankyrin repeat protein, selected binder, protein design, de novo protein/transferase
Biological source	RATTUS NORVEGICUS (NORWAY RAT) More
Cellular location	Nucleus (By similarity): P63086
Total number of polymer chains	4
Total formula weight	114329.96
Authors	Kummer, L.,Mittl, P.R.,Pluckthun, A. (deposition date: 2011-07-20, release date: 2012-06-27, Last modification date: 2023-12-20)
Primary citation	Kummer, L.,Parizek, P.,Rube, P.,Millgramm, B.,Prinz, A.,Mittl, P.R.,Kaufholz, M.,Zimmermann, B.,Herberg, F.W.,Pluckthun, A. Structural and Functional Analysis of Phosphorylation-Specific Binders of the Kinase Erk from Designed Ankyrin Repeat Protein Libraries. Proc.Natl.Acad.Sci.USA, 109:E2248-, 2012 Cited by PubMed: 22843676 DOI: 10.1073/PNAS.1205399109 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.72 Å)

Structure validation