3SL1

Crystal Structure of P. falciparum arginase complexed with 2-amino-6-borono-2-methylhexanoic acid

Summary for 3SL1

Entry DOI	10.2210/pdb3sl1/pdb
Related	3GMZ 3GN0 3MMR 3SJT 3SKK 3SL0
Descriptor	Arginase, MANGANESE (II) ION, 6-(dihydroxyboranyl)-2-methyl-L-norleucine, ... (4 entities in total)
Functional Keywords	metallohydrolase, arginase fold, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Plasmodium falciparum
Total number of polymer chains	1
Total formula weight	46750.93
Authors	Dowling, D.P.,Ilies, M.,Christianson, D.W. (deposition date: 2011-06-23, release date: 2011-07-20, Last modification date: 2023-09-13)
Primary citation	Ilies, M.,Di Costanzo, L.,Dowling, D.P.,Thorn, K.J.,Christianson, D.W. Binding of alpha , alpha-disubstituted amino acids to arginase suggests new avenues for inhibitor design. J.Med.Chem., 54:5432-5443, 2011 Cited by PubMed: 21728378 DOI: 10.1021/jm200443b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.902 Å)

Structure validation