3PP0

Crystal Structure of the Kinase domain of Human HER2 (erbB2).

Summary for 3PP0

• Entry DOI: 10.2210/pdb3pp0/pdb
• Related: 3POZ
• Descriptor: Receptor tyrosine-protein kinase erbB-2, 2-{2-[4-({5-chloro-6-[3-(trifluoromethyl)phenoxy]pyridin-3-yl}amino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy}ethanol (3 entities in total)
• Functional Keywords: kinase domain, anti-oncogene, atp-binding, cell cycle, disease mutation, glycoprotein, membrane, nucleotide-binding, phosphoprotein, receptor, secreted, transferase, transmembrane, tyrosine-protein kinase, tyrosine kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: P04626
• Total number of polymer chains: 2
• Total formula weight: 77445.76

Authors

Skene, R.J.,Aertgeerts, K.,Sogabe, S. (deposition date: 2010-11-23, release date: 2011-03-30, Last modification date: 2023-09-06)

• Primary citation: Aertgeerts, K.,Skene, R.,Yano, J.,Sang, B.C.,Zou, H.,Snell, G.,Jennings, A.,Iwamoto, K.,Habuka, N.,Hirokawa, A.,Ishikawa, T.,Tanaka, T.,Miki, H.,Ohta, Y.,Sogabe, S.; Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein.; J.Biol.Chem., 286:18756-18765, 2011; PubMed: 21454582; DOI: 10.1074/jbc.M110.206193

Experimental method

X-RAY DIFFRACTION (2.25 Å)