3LHJ

Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Pyrazolopyridinone Inhibitor.

Summary for 3LHJ

Entry DOI	10.2210/pdb3lhj/pdb
Related	1YQJ 3DS6 3DT1 3GFE 3ITZ
Descriptor	Mitogen-activated protein kinase 14, N-cyclopropyl-3-[1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-5-yl]-4-methylbenzamide (3 entities in total)
Functional Keywords	serine/threonine-protein kinase, transferase, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm (By similarity): Q16539
Total number of polymer chains	1
Total formula weight	42433.38
Authors	Mohr, C.,Jordan, S. (deposition date: 2010-01-22, release date: 2010-04-14, Last modification date: 2024-02-21)
Primary citation	Pettus, L.H.,Wurz, R.P.,Xu, S.,Herberich, B.,Henkle, B.,Liu, Q.,McBride, H.J.,Mu, S.,Plant, M.H.,Saris, C.J.,Sherman, L.,Wong, L.M.,Chmait, S.,Lee, M.R.,Mohr, C.,Hsieh, F.,Tasker, A.S. Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinase. J.Med.Chem., 53:2973-2985, 2010 Cited by PubMed: 20218619 DOI: 10.1021/jm100095x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.31 Å)

Structure validation