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3DS6

P38 complex with a phthalazine inhibitor

Summary for 3DS6
Entry DOI10.2210/pdb3ds6/pdb
DescriptorMitogen-activated protein kinase 14, N-cyclopropyl-4-methyl-3-[1-(2-methylphenyl)phthalazin-6-yl]benzamide (2 entities in total)
Functional Keywordskinase inhibitor complex, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm (By similarity): Q16539
Total number of polymer chains4
Total formula weight169569.67
Authors
Herberich, B.,Syed, R.,Li, V.,Grosfeld, D. (deposition date: 2008-07-11, release date: 2008-10-07, Last modification date: 2024-02-21)
Primary citationHerberich, B.,Cao, G.Q.,Chakrabarti, P.P.,Falsey, J.R.,Pettus, L.,Rzasa, R.M.,Reed, A.B.,Reichelt, A.,Sham, K.,Thaman, M.,Wurz, R.P.,Xu, S.,Zhang, D.,Hsieh, F.,Lee, M.R.,Syed, R.,Li, V.,Grosfeld, D.,Plant, M.H.,Henkle, B.,Sherman, L.,Middleton, S.,Wong, L.M.,Tasker, A.S.
Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold.
J.Med.Chem., 51:6271-6279, 2008
Cited by
PubMed: 18817365
DOI: 10.1021/jm8005417
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.9 Å)
Structure validation

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