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3DS6

P38 complex with a phthalazine inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0000077biological_processDNA damage checkpoint signaling
A0000165biological_processMAPK cascade
A0000166molecular_functionnucleotide binding
A0000902biological_processcell morphogenesis
A0000922cellular_componentspindle pole
A0001502biological_processcartilage condensation
A0001525biological_processangiogenesis
A0001649biological_processosteoblast differentiation
A0001890biological_processplacenta development
A0002021biological_processresponse to dietary excess
A0002062biological_processchondrocyte differentiation
A0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004707molecular_functionMAP kinase activity
A0004708molecular_functionMAP kinase kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0006006biological_processglucose metabolic process
A0006355biological_processregulation of DNA-templated transcription
A0006357biological_processregulation of transcription by RNA polymerase II
A0006366biological_processtranscription by RNA polymerase II
A0006468biological_processprotein phosphorylation
A0006915biological_processapoptotic process
A0006935biological_processchemotaxis
A0006974biological_processDNA damage response
A0007165biological_processsignal transduction
A0007166biological_processcell surface receptor signaling pathway
A0007178biological_processcell surface receptor protein serine/threonine kinase signaling pathway
A0007519biological_processskeletal muscle tissue development
A0010628biological_processpositive regulation of gene expression
A0010831biological_processpositive regulation of myotube differentiation
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016607cellular_componentnuclear speck
A0016740molecular_functiontransferase activity
A0018105biological_processpeptidyl-serine phosphorylation
A0019395biological_processfatty acid oxidation
A0019899molecular_functionenzyme binding
A0019903molecular_functionprotein phosphatase binding
A0030168biological_processplatelet activation
A0030278biological_processregulation of ossification
A0030316biological_processosteoclast differentiation
A0031098biological_processstress-activated protein kinase signaling cascade
A0031281biological_processpositive regulation of cyclase activity
A0031663biological_processlipopolysaccharide-mediated signaling pathway
A0032495biological_processresponse to muramyl dipeptide
A0032496biological_processresponse to lipopolysaccharide
A0032735biological_processpositive regulation of interleukin-12 production
A0032868biological_processresponse to insulin
A0033554biological_processcellular response to stress
A0034774cellular_componentsecretory granule lumen
A0035331biological_processnegative regulation of hippo signaling
A0035556biological_processintracellular signal transduction
A0035924biological_processcellular response to vascular endothelial growth factor stimulus
A0035994biological_processresponse to muscle stretch
A0038066biological_processp38MAPK cascade
A0042307biological_processpositive regulation of protein import into nucleus
A0042770biological_processsignal transduction in response to DNA damage
A0043536biological_processpositive regulation of blood vessel endothelial cell migration
A0045648biological_processpositive regulation of erythrocyte differentiation
A0045663biological_processpositive regulation of myoblast differentiation
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046323biological_processglucose import
A0046326biological_processpositive regulation of glucose import
A0048010biological_processvascular endothelial growth factor receptor signaling pathway
A0048273molecular_functionmitogen-activated protein kinase p38 binding
A0048863biological_processstem cell differentiation
A0051146biological_processstriated muscle cell differentiation
A0051149biological_processpositive regulation of muscle cell differentiation
A0051403biological_processstress-activated MAPK cascade
A0051525molecular_functionNFAT protein binding
A0060045biological_processpositive regulation of cardiac muscle cell proliferation
A0060348biological_processbone development
A0070935biological_process3'-UTR-mediated mRNA stabilization
A0071222biological_processcellular response to lipopolysaccharide
A0071223biological_processcellular response to lipoteichoic acid
A0071356biological_processcellular response to tumor necrosis factor
A0071479biological_processcellular response to ionizing radiation
A0071493biological_processcellular response to UV-B
A0090090biological_processnegative regulation of canonical Wnt signaling pathway
A0090336biological_processpositive regulation of brown fat cell differentiation
A0090398biological_processcellular senescence
A0090400biological_processstress-induced premature senescence
A0098586biological_processcellular response to virus
A0098978cellular_componentglutamatergic synapse
A0099179biological_processregulation of synaptic membrane adhesion
A0106310molecular_functionprotein serine kinase activity
A1900015biological_processregulation of cytokine production involved in inflammatory response
A1901741biological_processpositive regulation of myoblast fusion
A1904813cellular_componentficolin-1-rich granule lumen
A2000379biological_processpositive regulation of reactive oxygen species metabolic process
B0000077biological_processDNA damage checkpoint signaling
B0000165biological_processMAPK cascade
B0000166molecular_functionnucleotide binding
B0000902biological_processcell morphogenesis
B0000922cellular_componentspindle pole
B0001502biological_processcartilage condensation
B0001525biological_processangiogenesis
B0001649biological_processosteoblast differentiation
B0001890biological_processplacenta development
B0002021biological_processresponse to dietary excess
B0002062biological_processchondrocyte differentiation
B0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004707molecular_functionMAP kinase activity
B0004708molecular_functionMAP kinase kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0006006biological_processglucose metabolic process
B0006355biological_processregulation of DNA-templated transcription
B0006357biological_processregulation of transcription by RNA polymerase II
B0006366biological_processtranscription by RNA polymerase II
B0006468biological_processprotein phosphorylation
B0006915biological_processapoptotic process
B0006935biological_processchemotaxis
B0006974biological_processDNA damage response
B0007165biological_processsignal transduction
B0007166biological_processcell surface receptor signaling pathway
B0007178biological_processcell surface receptor protein serine/threonine kinase signaling pathway
B0007519biological_processskeletal muscle tissue development
B0010628biological_processpositive regulation of gene expression
B0010831biological_processpositive regulation of myotube differentiation
B0016301molecular_functionkinase activity
B0016310biological_processphosphorylation
B0016607cellular_componentnuclear speck
B0016740molecular_functiontransferase activity
B0018105biological_processpeptidyl-serine phosphorylation
B0019395biological_processfatty acid oxidation
B0019899molecular_functionenzyme binding
B0019903molecular_functionprotein phosphatase binding
B0030168biological_processplatelet activation
B0030278biological_processregulation of ossification
B0030316biological_processosteoclast differentiation
B0031098biological_processstress-activated protein kinase signaling cascade
B0031281biological_processpositive regulation of cyclase activity
B0031663biological_processlipopolysaccharide-mediated signaling pathway
B0032495biological_processresponse to muramyl dipeptide
B0032496biological_processresponse to lipopolysaccharide
B0032735biological_processpositive regulation of interleukin-12 production
B0032868biological_processresponse to insulin
B0033554biological_processcellular response to stress
B0034774cellular_componentsecretory granule lumen
B0035331biological_processnegative regulation of hippo signaling
B0035556biological_processintracellular signal transduction
B0035924biological_processcellular response to vascular endothelial growth factor stimulus
B0035994biological_processresponse to muscle stretch
B0038066biological_processp38MAPK cascade
B0042307biological_processpositive regulation of protein import into nucleus
B0042770biological_processsignal transduction in response to DNA damage
B0043536biological_processpositive regulation of blood vessel endothelial cell migration
B0045648biological_processpositive regulation of erythrocyte differentiation
B0045663biological_processpositive regulation of myoblast differentiation
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046323biological_processglucose import
B0046326biological_processpositive regulation of glucose import
B0048010biological_processvascular endothelial growth factor receptor signaling pathway
B0048273molecular_functionmitogen-activated protein kinase p38 binding
B0048863biological_processstem cell differentiation
B0051146biological_processstriated muscle cell differentiation
B0051149biological_processpositive regulation of muscle cell differentiation
B0051403biological_processstress-activated MAPK cascade
B0051525molecular_functionNFAT protein binding
B0060045biological_processpositive regulation of cardiac muscle cell proliferation
B0060348biological_processbone development
B0070935biological_process3'-UTR-mediated mRNA stabilization
B0071222biological_processcellular response to lipopolysaccharide
B0071223biological_processcellular response to lipoteichoic acid
B0071356biological_processcellular response to tumor necrosis factor
B0071479biological_processcellular response to ionizing radiation
B0071493biological_processcellular response to UV-B
B0090090biological_processnegative regulation of canonical Wnt signaling pathway
B0090336biological_processpositive regulation of brown fat cell differentiation
B0090398biological_processcellular senescence
B0090400biological_processstress-induced premature senescence
B0098586biological_processcellular response to virus
B0098978cellular_componentglutamatergic synapse
B0099179biological_processregulation of synaptic membrane adhesion
B0106310molecular_functionprotein serine kinase activity
B1900015biological_processregulation of cytokine production involved in inflammatory response
B1901741biological_processpositive regulation of myoblast fusion
B1904813cellular_componentficolin-1-rich granule lumen
B2000379biological_processpositive regulation of reactive oxygen species metabolic process
C0000077biological_processDNA damage checkpoint signaling
C0000165biological_processMAPK cascade
C0000166molecular_functionnucleotide binding
C0000902biological_processcell morphogenesis
C0000922cellular_componentspindle pole
C0001502biological_processcartilage condensation
C0001525biological_processangiogenesis
C0001649biological_processosteoblast differentiation
C0001890biological_processplacenta development
C0002021biological_processresponse to dietary excess
C0002062biological_processchondrocyte differentiation
C0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0004707molecular_functionMAP kinase activity
C0004708molecular_functionMAP kinase kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0006006biological_processglucose metabolic process
C0006355biological_processregulation of DNA-templated transcription
C0006357biological_processregulation of transcription by RNA polymerase II
C0006366biological_processtranscription by RNA polymerase II
C0006468biological_processprotein phosphorylation
C0006915biological_processapoptotic process
C0006935biological_processchemotaxis
C0006974biological_processDNA damage response
C0007165biological_processsignal transduction
C0007166biological_processcell surface receptor signaling pathway
C0007178biological_processcell surface receptor protein serine/threonine kinase signaling pathway
C0007519biological_processskeletal muscle tissue development
C0010628biological_processpositive regulation of gene expression
C0010831biological_processpositive regulation of myotube differentiation
C0016301molecular_functionkinase activity
C0016310biological_processphosphorylation
C0016607cellular_componentnuclear speck
C0016740molecular_functiontransferase activity
C0018105biological_processpeptidyl-serine phosphorylation
C0019395biological_processfatty acid oxidation
C0019899molecular_functionenzyme binding
C0019903molecular_functionprotein phosphatase binding
C0030168biological_processplatelet activation
C0030278biological_processregulation of ossification
C0030316biological_processosteoclast differentiation
C0031098biological_processstress-activated protein kinase signaling cascade
C0031281biological_processpositive regulation of cyclase activity
C0031663biological_processlipopolysaccharide-mediated signaling pathway
C0032495biological_processresponse to muramyl dipeptide
C0032496biological_processresponse to lipopolysaccharide
C0032735biological_processpositive regulation of interleukin-12 production
C0032868biological_processresponse to insulin
C0033554biological_processcellular response to stress
C0034774cellular_componentsecretory granule lumen
C0035331biological_processnegative regulation of hippo signaling
C0035556biological_processintracellular signal transduction
C0035924biological_processcellular response to vascular endothelial growth factor stimulus
C0035994biological_processresponse to muscle stretch
C0038066biological_processp38MAPK cascade
C0042307biological_processpositive regulation of protein import into nucleus
C0042770biological_processsignal transduction in response to DNA damage
C0043536biological_processpositive regulation of blood vessel endothelial cell migration
C0045648biological_processpositive regulation of erythrocyte differentiation
C0045663biological_processpositive regulation of myoblast differentiation
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0046323biological_processglucose import
C0046326biological_processpositive regulation of glucose import
C0048010biological_processvascular endothelial growth factor receptor signaling pathway
C0048273molecular_functionmitogen-activated protein kinase p38 binding
C0048863biological_processstem cell differentiation
C0051146biological_processstriated muscle cell differentiation
C0051149biological_processpositive regulation of muscle cell differentiation
C0051403biological_processstress-activated MAPK cascade
C0051525molecular_functionNFAT protein binding
C0060045biological_processpositive regulation of cardiac muscle cell proliferation
C0060348biological_processbone development
C0070935biological_process3'-UTR-mediated mRNA stabilization
C0071222biological_processcellular response to lipopolysaccharide
C0071223biological_processcellular response to lipoteichoic acid
C0071356biological_processcellular response to tumor necrosis factor
C0071479biological_processcellular response to ionizing radiation
C0071493biological_processcellular response to UV-B
C0090090biological_processnegative regulation of canonical Wnt signaling pathway
C0090336biological_processpositive regulation of brown fat cell differentiation
C0090398biological_processcellular senescence
C0090400biological_processstress-induced premature senescence
C0098586biological_processcellular response to virus
C0098978cellular_componentglutamatergic synapse
C0099179biological_processregulation of synaptic membrane adhesion
C0106310molecular_functionprotein serine kinase activity
C1900015biological_processregulation of cytokine production involved in inflammatory response
C1901741biological_processpositive regulation of myoblast fusion
C1904813cellular_componentficolin-1-rich granule lumen
C2000379biological_processpositive regulation of reactive oxygen species metabolic process
D0000077biological_processDNA damage checkpoint signaling
D0000165biological_processMAPK cascade
D0000166molecular_functionnucleotide binding
D0000902biological_processcell morphogenesis
D0000922cellular_componentspindle pole
D0001502biological_processcartilage condensation
D0001525biological_processangiogenesis
D0001649biological_processosteoblast differentiation
D0001890biological_processplacenta development
D0002021biological_processresponse to dietary excess
D0002062biological_processchondrocyte differentiation
D0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
D0004672molecular_functionprotein kinase activity
D0004674molecular_functionprotein serine/threonine kinase activity
D0004707molecular_functionMAP kinase activity
D0004708molecular_functionMAP kinase kinase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005829cellular_componentcytosol
D0006006biological_processglucose metabolic process
D0006355biological_processregulation of DNA-templated transcription
D0006357biological_processregulation of transcription by RNA polymerase II
D0006366biological_processtranscription by RNA polymerase II
D0006468biological_processprotein phosphorylation
D0006915biological_processapoptotic process
D0006935biological_processchemotaxis
D0006974biological_processDNA damage response
D0007165biological_processsignal transduction
D0007166biological_processcell surface receptor signaling pathway
D0007178biological_processcell surface receptor protein serine/threonine kinase signaling pathway
D0007519biological_processskeletal muscle tissue development
D0010628biological_processpositive regulation of gene expression
D0010831biological_processpositive regulation of myotube differentiation
D0016301molecular_functionkinase activity
D0016310biological_processphosphorylation
D0016607cellular_componentnuclear speck
D0016740molecular_functiontransferase activity
D0018105biological_processpeptidyl-serine phosphorylation
D0019395biological_processfatty acid oxidation
D0019899molecular_functionenzyme binding
D0019903molecular_functionprotein phosphatase binding
D0030168biological_processplatelet activation
D0030278biological_processregulation of ossification
D0030316biological_processosteoclast differentiation
D0031098biological_processstress-activated protein kinase signaling cascade
D0031281biological_processpositive regulation of cyclase activity
D0031663biological_processlipopolysaccharide-mediated signaling pathway
D0032495biological_processresponse to muramyl dipeptide
D0032496biological_processresponse to lipopolysaccharide
D0032735biological_processpositive regulation of interleukin-12 production
D0032868biological_processresponse to insulin
D0033554biological_processcellular response to stress
D0034774cellular_componentsecretory granule lumen
D0035331biological_processnegative regulation of hippo signaling
D0035556biological_processintracellular signal transduction
D0035924biological_processcellular response to vascular endothelial growth factor stimulus
D0035994biological_processresponse to muscle stretch
D0038066biological_processp38MAPK cascade
D0042307biological_processpositive regulation of protein import into nucleus
D0042770biological_processsignal transduction in response to DNA damage
D0043536biological_processpositive regulation of blood vessel endothelial cell migration
D0045648biological_processpositive regulation of erythrocyte differentiation
D0045663biological_processpositive regulation of myoblast differentiation
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046323biological_processglucose import
D0046326biological_processpositive regulation of glucose import
D0048010biological_processvascular endothelial growth factor receptor signaling pathway
D0048273molecular_functionmitogen-activated protein kinase p38 binding
D0048863biological_processstem cell differentiation
D0051146biological_processstriated muscle cell differentiation
D0051149biological_processpositive regulation of muscle cell differentiation
D0051403biological_processstress-activated MAPK cascade
D0051525molecular_functionNFAT protein binding
D0060045biological_processpositive regulation of cardiac muscle cell proliferation
D0060348biological_processbone development
D0070935biological_process3'-UTR-mediated mRNA stabilization
D0071222biological_processcellular response to lipopolysaccharide
D0071223biological_processcellular response to lipoteichoic acid
D0071356biological_processcellular response to tumor necrosis factor
D0071479biological_processcellular response to ionizing radiation
D0071493biological_processcellular response to UV-B
D0090090biological_processnegative regulation of canonical Wnt signaling pathway
D0090336biological_processpositive regulation of brown fat cell differentiation
D0090398biological_processcellular senescence
D0090400biological_processstress-induced premature senescence
D0098586biological_processcellular response to virus
D0098978cellular_componentglutamatergic synapse
D0099179biological_processregulation of synaptic membrane adhesion
D0106310molecular_functionprotein serine kinase activity
D1900015biological_processregulation of cytokine production involved in inflammatory response
D1901741biological_processpositive regulation of myoblast fusion
D1904813cellular_componentficolin-1-rich granule lumen
D2000379biological_processpositive regulation of reactive oxygen species metabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE A17 A 361
ChainResidue
ATYR35
ALEU167
AASP168
APHE169
ALYS53
AGLU71
ATHR106
AHIS107
ALEU108
AMET109
AGLY110
AALA111

site_idAC2
Number of Residues14
DetailsBINDING SITE FOR RESIDUE A17 B 361
ChainResidue
BTYR35
BLYS53
BGLU71
BLEU75
BTHR106
BHIS107
BLEU108
BMET109
BGLY110
BALA111
BASP112
BALA157
BLEU167
BASP168

site_idAC3
Number of Residues11
DetailsBINDING SITE FOR RESIDUE A17 C 361
ChainResidue
CGLU71
CTHR106
CHIS107
CLEU108
CMET109
CGLY110
CALA111
CASP112
CALA157
CLEU167
CASP168

site_idAC4
Number of Residues11
DetailsBINDING SITE FOR RESIDUE A17 D 361
ChainResidue
DTYR35
DLYS53
DLEU75
DILE84
DTHR106
DHIS107
DLEU108
DMET109
DGLY110
DALA111
DASP168

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues25
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGAYGSVCaAfdtktglrv.........AVKK
ChainResidueDetails
AVAL30-LYS54

site_idPS01351
Number of Residues104
DetailsMAPK MAP kinase signature. FqsiihakrtyRElrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltddhvqfliyqilrglkyihsadiih.........RDlKpsnlavnedC
ChainResidueDetails
APHE59-CYS162

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
AASP168
BASP168
CASP168
DASP168

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING:
ChainResidueDetails
AVAL30
ALYS53
BVAL30
BLYS53
CVAL30
CLYS53
DVAL30
DLYS53

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER2
BSER2
CSER2
DSER2

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976
ChainResidueDetails
ATHR16
BTHR16
CTHR16
DTHR16

site_idSWS_FT_FI5
Number of Residues8
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:21444723
ChainResidueDetails
ALYS53
ALYS152
BLYS53
BLYS152
CLYS53
CLYS152
DLYS53
DLYS152

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphothreonine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis => ECO:0000269|PubMed:7535770, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR180
BTHR180
CTHR180
DTHR180

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphotyrosine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis => ECO:0000269|PubMed:7535770, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ATYR182
BTYR182
CTYR182
DTYR182

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:17525332
ChainResidueDetails
ATHR263
BTHR263
CTHR263
DTHR263

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphotyrosine; by ZAP70 => ECO:0000269|PubMed:15735648
ChainResidueDetails
ATYR323
BTYR323
CTYR323
DTYR323

218853

PDB entries from 2024-04-24

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