3DT1

P38 Complexed with a quinazoline inhibitor

Summary for 3DT1

• Entry DOI: 10.2210/pdb3dt1/pdb
• Related: 3ds6
• Descriptor: Mitogen-activated protein kinase 14, N-cyclopropyl-4-methyl-3-{2-[(2-morpholin-4-ylethyl)amino]quinazolin-6-yl}benzamide (3 entities in total)
• Functional Keywords: kinase inhibitor complex, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm (By similarity): Q16539
• Total number of polymer chains: 1
• Total formula weight: 44319.54

Authors

Herberich, B.,Syed, R.,Li, V.,Tasker, A.S. (deposition date: 2008-07-14, release date: 2008-10-14, Last modification date: 2024-02-21)

• Primary citation: Herberich, B.,Cao, G.Q.,Chakrabarti, P.P.,Falsey, J.R.,Pettus, L.,Rzasa, R.M.,Reed, A.B.,Reichelt, A.,Sham, K.,Thaman, M.,Wurz, R.P.,Xu, S.,Zhang, D.,Hsieh, F.,Lee, M.R.,Syed, R.,Li, V.,Grosfeld, D.,Plant, M.H.,Henkle, B.,Sherman, L.,Middleton, S.,Wong, L.M.,Tasker, A.S.; Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold.; J.Med.Chem., 51:6271-6279, 2008; PubMed: 18817365; DOI: 10.1021/jm8005417

Experimental method

X-RAY DIFFRACTION (2.8 Å)