3GFE

Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Pyrazolopyridinone Inhibitor

Summary for 3GFE

Entry DOI	10.2210/pdb3gfe/pdb
Related	1YQJ 3DS6 3DT1
Descriptor	Mitogen-activated protein kinase 14, N-cyclopropyl-3-{[1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}-4-methylbenzamide (3 entities in total)
Functional Keywords	serine/threonine-protein kinase, transferase, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm (By similarity): Q16539
Total number of polymer chains	1
Total formula weight	42448.39
Authors	Mohr, C.,Jordan, S. (deposition date: 2009-02-26, release date: 2009-07-14, Last modification date: 2024-02-21)
Primary citation	Wurz, R.P.,Pettus, L.H.,Xu, S.,Henkle, B.,Sherman, L.,Plant, M.,Miner, K.,McBride, H.,Wong, L.M.,Saris, C.J.,Lee, M.R.,Chmait, S.,Mohr, C.,Hsieh, F.,Tasker, A.S. Part 1: Structure-Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase. Bioorg.Med.Chem.Lett., 19:4724-4728, 2009 Cited by PubMed: 19574047 DOI: 10.1016/j.bmcl.2009.06.058 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation