3H6T
Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and cyclothiazide at 2.25 A resolution
Summary for 3H6T
Entry DOI | 10.2210/pdb3h6t/pdb |
Related | 1LBC 3H6U 3H6V 3H6W |
Descriptor | Glutamate receptor 2, GLUTAMIC ACID, CYCLOTHIAZIDE, ... (9 entities in total) |
Functional Keywords | ampa receptor ligand-binding core, iglur2 s1s2j-n754s, cyclothiazide, allosteric modulation, membrane protein |
Biological source | Rattus norvegicus (rat) More |
Cellular location | Cell membrane; Multi-pass membrane protein: P19491 |
Total number of polymer chains | 3 |
Total formula weight | 91011.14 |
Authors | Hald, H.,Gajhede, M.,Kastrup, J.S. (deposition date: 2009-04-24, release date: 2009-07-28, Last modification date: 2023-09-06) |
Primary citation | Hald, H.,Ahring, P.K.,Timmermann, D.B.,Liljefors, T.,Gajhede, M.,Kastrup, J.S. Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2. J.Mol.Biol., 391:906-917, 2009 Cited by PubMed: 19591837DOI: 10.1016/j.jmb.2009.07.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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