3H6W
Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS5217 at 1.50 A resolution
Summary for 3H6W
Entry DOI | 10.2210/pdb3h6w/pdb |
Related | 1LBC 3H6T 3H6U 3H6V |
Descriptor | Glutamate receptor 2, GLUTAMIC ACID, (3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide, ... (7 entities in total) |
Functional Keywords | ampa receptor ligand-binding core, iglur2 s1s2j-n754s, allosteric modulation, membrane protein |
Biological source | Rattus norvegicus (rat) More |
Cellular location | Cell membrane; Multi-pass membrane protein: P19491 |
Total number of polymer chains | 2 |
Total formula weight | 59901.09 |
Authors | Hald, H.,Gajhede, M.,Kastrup, J.S. (deposition date: 2009-04-24, release date: 2009-07-28, Last modification date: 2023-09-06) |
Primary citation | Hald, H.,Ahring, P.K.,Timmermann, D.B.,Liljefors, T.,Gajhede, M.,Kastrup, J.S. Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2. J.Mol.Biol., 391:906-917, 2009 Cited by PubMed: 19591837DOI: 10.1016/j.jmb.2009.07.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.49 Å) |
Structure validation
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