3H6W

Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS5217 at 1.50 A resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Glutamate receptor 2	polymer	263	29194.7	2	UniProt (P19491) Pfam (PF10613) Pfam (PF00060) In PDB	Rattus norvegicus (rat)	GluR-2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, AMPA-selective glutamate receptor 2
2	A, B	GLUTAMIC ACID	non-polymer		147.1	2	Chemie (GLU)
3	A, B	(3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide	non-polymer		427.6	2	Chemie (NS7)
4	A, B	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
5	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
6	B	DIMETHYL SULFOXIDE	non-polymer		78.1	1	Chemie (DMS)
7		water	water		18.0	683	Chemie (HOH)

Sequence modifications

A, B: 3 - 117 (UniProt: P19491)

PDB	External Database	Details
Gly 1	-	expression tag
Ala 2	-	expression tag

A, B: 120 - 263 (UniProt: P19491)

PDB	External Database	Details
Gly 118	-	linker
Thr 119	-	linker
Ser 242	Asn 775	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	58389.3
Non-Polymers*	Number of molecules	8
	Total formula weight	1511.8
All*	Total formula weight	59901.1

*Water molecules are not included.