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3H6T

Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and cyclothiazide at 2.25 A resolution

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, CGlutamate receptor 2polymer26329194.73UniProt (P19491)
Pfam (PF10613)
Pfam (PF00060)
In PDB
Rattus norvegicus (rat)GluR-2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, AMPA-selective glutamate receptor 2
2A, B, CGLUTAMIC ACIDnon-polymer147.13Chemie (GLU)
3A, B, CCYCLOTHIAZIDEnon-polymer389.93Chemie (CYZ)
4C, A, BZINC IONnon-polymer65.410Chemie (ZN)
5C, A, BGLYCEROLnon-polymer92.19Chemie (GOL)
6C, AACETATE IONnon-polymer59.02Chemie (ACT)
7ADIMETHYL SULFOXIDEnon-polymer78.11Chemie (DMS)
8BCACODYLATE IONnon-polymer137.01Chemie (CAC)
9waterwater18.01031Chemie (HOH)
Sequence modifications
A, B, C: 3 - 117 (UniProt: P19491)
PDBExternal DatabaseDetails
Gly 1-expression tag
Ala 2-expression tag
A, B, C: 120 - 263 (UniProt: P19491)
PDBExternal DatabaseDetails
Gly 118-linker
Thr 119-linker
Ser 242Asn 775engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight87584.0
Non-Polymers*Number of molecules29
Total formula weight3427.2
All*Total formula weight91011.1
*Water molecules are not included.

222036

PDB entries from 2024-07-03

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