3H6T
Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and cyclothiazide at 2.25 A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Glutamate receptor 2 | polymer | 263 | 29194.7 | 3 | UniProt (P19491) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (rat) | GluR-2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, AMPA-selective glutamate receptor 2 |
| 2 | D, M, X (A, B, C) | GLUTAMIC ACID | non-polymer | 147.1 | 3 | Chemie (GLU) | |||
| 3 | E, N, Y (A, B, C) | CYCLOTHIAZIDE | non-polymer | 389.9 | 3 | Chemie (CYZ) | |||
| 4 | AA, F, G, H, O... (C, A, B) | ZINC ION | non-polymer | 65.4 | 10 | Chemie (ZN) | |||
| 5 | BA, CA, DA, EA, I... (C, A, B) | GLYCEROL | non-polymer | 92.1 | 9 | Chemie (GOL) | |||
| 6 | FA, K (C, A) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 7 | L (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 8 | W (B) | CACODYLATE ION | non-polymer | 137.0 | 1 | Chemie (CAC) | |||
| 9 | GA, HA, IA (A, B, C) | water | water | 18.0 | 1031 | Chemie (HOH) |
Sequence modifications
A, B, C: 3 - 117 (UniProt: P19491)
A, B, C: 120 - 263 (UniProt: P19491)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Ala 2 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 118 | - | linker |
| Thr 119 | - | linker |
| Ser 242 | Asn 775 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 87584.0 | |
| Non-Polymers* | Number of molecules | 29 |
| Total formula weight | 3427.2 | |
| All* | Total formula weight | 91011.1 |
