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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3H6T

Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and cyclothiazide at 2.25 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU A 264

Chain	Residue
A	TYR61
A	GLU193
A	TYR220
A	HOH277
A	HOH360
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	LEU138
A	GLY141
A	SER142
A	THR143

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE CYZ A 265

Chain	Residue
A	PRO105
A	MET107
A	SER108
A	LEU239
A	SER242
A	LEU247
A	ASP248
A	HOH281
A	HOH328
A	HOH351
A	HOH356
C	SER217
C	LYS218
C	GLY219
C	HOH473

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 266

Chain	Residue
A	GLU42
A	HIS46
B	GLU166
B	CAC274

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 267

Chain	Residue
A	HIS23
A	ACT271
A	HOH843
C	ASP65

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 268

Chain	Residue
A	GLU122
A	ASP126
A	HOH566
A	HOH955

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 269

Chain	Residue
A	GLU24
A	HOH623
A	HOH983
C	LYS60
C	ASP139
C	ARG172

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 270

Chain	Residue
A	ASN214
A	ASP216
A	SER217
A	HOH337
A	HOH462
C	ASP248
C	CYZ265

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT A 271

Chain	Residue
A	HIS23
A	ZN267
C	ASP65

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS A 272

Chain	Residue
A	GLU201
A	LYS210

site_id	BC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU B 264

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	GLY141
B	SER142
B	THR143
B	GLU193
B	TYR220
B	HOH277
B	HOH285
B	HOH287

site_id	BC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CYZ B 265

Chain	Residue
B	PRO105
B	MET107
B	SER108
B	SER217
B	LYS218
B	GLY219
B	LEU239
B	SER242
B	ASP248
B	HOH306
B	HOH336
B	HOH429

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 266

Chain	Residue
A	GLU166
B	GLU42
B	HIS46
B	LEU241
B	HOH971

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 267

Chain	Residue
B	HIS23
B	GLU30
B	HOH859
C	HIS23

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN B 268

Chain	Residue
B	ASP156
B	HOH390

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN B 269

Chain	Residue
B	ASP126
B	HOH952

site_id	BC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN B 270

Chain	Residue
B	GLU201

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL B 271

Chain	Residue
B	ILE70
B	HOH1006

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 272

Chain	Residue
A	HOH792
B	LEU12
B	MET19
B	HOH449

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 273

Chain	Residue
B	VAL7
B	LYS52
B	LYS82
B	HOH945

site_id	CC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CAC B 274

Chain	Residue
A	GLU42
A	HIS46
A	ZN266
B	ARG163
B	ALA165
B	GLU166
B	SER168
B	PHE170

site_id	CC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU C 264

Chain	Residue
C	TYR61
C	PRO89
C	LEU90
C	THR91
C	ARG96
C	LEU138
C	GLY141
C	SER142
C	THR143
C	GLU193
C	HOH280
C	HOH281
C	HOH284

site_id	CC4
Number of Residues	17
Details	BINDING SITE FOR RESIDUE CYZ C 265

Chain	Residue
A	SER217
A	LYS218
A	GLY219
A	GOL270
A	HOH356
C	LYS104
C	PRO105
C	MET107
C	SER108
C	LEU239
C	SER242
C	LEU247
C	ASP248
C	HOH273
C	HOH323
C	HOH346
C	HOH473

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 266

Chain	Residue
C	GLU42
C	LYS45
C	HIS46
C	HOH339
C	HOH342

site_id	CC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN C 267

Chain	Residue
C	ASP156
C	HOH632

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL C 268

Chain	Residue
C	LYS82
C	HOH504
C	HOH600

site_id	CC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL C 269

Chain	Residue
C	LYS4
C	GLY81
C	ASP84
C	LYS204
C	PRO205
C	CYS206
C	HOH374

site_id	CC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL C 270

Chain	Residue
C	LYS117
C	GLY118
C	THR119
C	PRO120
C	LYS185
C	GLY186
C	HOH504
C	HOH767
C	HOH837

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 271

Chain	Residue
A	LEU236
A	HOH1025
C	GLU97
C	GLU98
C	LYS226
C	HOH964

site_id	DC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT C 272

Chain	Residue
C	GLU201
C	LYS210

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269\|PubMed:11086992, ECO:0000269\|PubMed:16483599, ECO:0007744\|PDB:1FTJ, ECO:0007744\|PDB:2CMO

Chain	Residue	Details
A	PRO89
B	SER142
B	THR143
B	GLU193
C	PRO89
C	THR91
C	ARG96
C	SER142
C	THR143
C	GLU193
A	THR91
A	ARG96
A	SER142
A	THR143
A	GLU193
B	PRO89
B	THR91
B	ARG96

site_id	SWS_FT_FI2
Number of Residues	9
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269\|PubMed:25103405

Chain	Residue	Details
A	ARG64
A	ARG148
A	LYS240
B	ARG64
B	ARG148
B	LYS240
C	ARG64
C	ARG148
C	LYS240

site_id	SWS_FT_FI3
Number of Residues	3
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269\|PubMed:25103405

Chain	Residue	Details
A	ILE121
B	ILE121
C	ILE121

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269\|PubMed:8848293

Chain	Residue	Details
A	SER150
B	SER150
C	SER150

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269\|PubMed:8848293

Chain	Residue	Details
A	SER184
B	SER184
C	SER184

site_id	SWS_FT_FI6
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
B	ASN3
C	ASN3

222036

PDB entries from 2024-07-03

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