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3H6T

Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and cyclothiazide at 2.25 A resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0016020cellular_componentmembrane
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0016020cellular_componentmembrane
C0015276molecular_functionligand-gated monoatomic ion channel activity
C0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE GLU A 264
ChainResidue
ATYR61
AGLU193
ATYR220
AHOH277
AHOH360
APRO89
ALEU90
ATHR91
AARG96
ALEU138
AGLY141
ASER142
ATHR143

site_idAC2
Number of Residues15
DetailsBINDING SITE FOR RESIDUE CYZ A 265
ChainResidue
APRO105
AMET107
ASER108
ALEU239
ASER242
ALEU247
AASP248
AHOH281
AHOH328
AHOH351
AHOH356
CSER217
CLYS218
CGLY219
CHOH473

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 266
ChainResidue
AGLU42
AHIS46
BGLU166
BCAC274

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 267
ChainResidue
AHIS23
AACT271
AHOH843
CASP65

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 268
ChainResidue
AGLU122
AASP126
AHOH566
AHOH955

site_idAC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL A 269
ChainResidue
AGLU24
AHOH623
AHOH983
CLYS60
CASP139
CARG172

site_idAC7
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 270
ChainResidue
AASN214
AASP216
ASER217
AHOH337
AHOH462
CASP248
CCYZ265

site_idAC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE ACT A 271
ChainResidue
AHIS23
AZN267
CASP65

site_idAC9
Number of Residues2
DetailsBINDING SITE FOR RESIDUE DMS A 272
ChainResidue
AGLU201
ALYS210

site_idBC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE GLU B 264
ChainResidue
BTYR61
BPRO89
BLEU90
BTHR91
BARG96
BGLY141
BSER142
BTHR143
BGLU193
BTYR220
BHOH277
BHOH285
BHOH287

site_idBC2
Number of Residues12
DetailsBINDING SITE FOR RESIDUE CYZ B 265
ChainResidue
BPRO105
BMET107
BSER108
BSER217
BLYS218
BGLY219
BLEU239
BSER242
BASP248
BHOH306
BHOH336
BHOH429

site_idBC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN B 266
ChainResidue
AGLU166
BGLU42
BHIS46
BLEU241
BHOH971

site_idBC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 267
ChainResidue
BHIS23
BGLU30
BHOH859
CHIS23

site_idBC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE ZN B 268
ChainResidue
BASP156
BHOH390

site_idBC6
Number of Residues2
DetailsBINDING SITE FOR RESIDUE ZN B 269
ChainResidue
BASP126
BHOH952

site_idBC7
Number of Residues1
DetailsBINDING SITE FOR RESIDUE ZN B 270
ChainResidue
BGLU201

site_idBC8
Number of Residues2
DetailsBINDING SITE FOR RESIDUE GOL B 271
ChainResidue
BILE70
BHOH1006

site_idBC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL B 272
ChainResidue
AHOH792
BLEU12
BMET19
BHOH449

site_idCC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL B 273
ChainResidue
BVAL7
BLYS52
BLYS82
BHOH945

site_idCC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE CAC B 274
ChainResidue
AGLU42
AHIS46
AZN266
BARG163
BALA165
BGLU166
BSER168
BPHE170

site_idCC3
Number of Residues13
DetailsBINDING SITE FOR RESIDUE GLU C 264
ChainResidue
CTYR61
CPRO89
CLEU90
CTHR91
CARG96
CLEU138
CGLY141
CSER142
CTHR143
CGLU193
CHOH280
CHOH281
CHOH284

site_idCC4
Number of Residues17
DetailsBINDING SITE FOR RESIDUE CYZ C 265
ChainResidue
ASER217
ALYS218
AGLY219
AGOL270
AHOH356
CLYS104
CPRO105
CMET107
CSER108
CLEU239
CSER242
CLEU247
CASP248
CHOH273
CHOH323
CHOH346
CHOH473

site_idCC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN C 266
ChainResidue
CGLU42
CLYS45
CHIS46
CHOH339
CHOH342

site_idCC6
Number of Residues2
DetailsBINDING SITE FOR RESIDUE ZN C 267
ChainResidue
CASP156
CHOH632

site_idCC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL C 268
ChainResidue
CLYS82
CHOH504
CHOH600

site_idCC8
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL C 269
ChainResidue
CLYS4
CGLY81
CASP84
CLYS204
CPRO205
CCYS206
CHOH374

site_idCC9
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GOL C 270
ChainResidue
CLYS117
CGLY118
CTHR119
CPRO120
CLYS185
CGLY186
CHOH504
CHOH767
CHOH837

site_idDC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL C 271
ChainResidue
ALEU236
AHOH1025
CGLU97
CGLU98
CLYS226
CHOH964

site_idDC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE ACT C 272
ChainResidue
CGLU201
CLYS210

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues18
DetailsBINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO
ChainResidueDetails
APRO89
BSER142
BTHR143
BGLU193
CPRO89
CTHR91
CARG96
CSER142
CTHR143
CGLU193
ATHR91
AARG96
ASER142
ATHR143
AGLU193
BPRO89
BTHR91
BARG96

site_idSWS_FT_FI2
Number of Residues9
DetailsSITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405
ChainResidueDetails
AARG64
AARG148
ALYS240
BARG64
BARG148
BLYS240
CARG64
CARG148
CLYS240

site_idSWS_FT_FI3
Number of Residues3
DetailsSITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405
ChainResidueDetails
AILE121
BILE121
CILE121

site_idSWS_FT_FI4
Number of Residues3
DetailsMOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293
ChainResidueDetails
ASER150
BSER150
CSER150

site_idSWS_FT_FI5
Number of Residues3
DetailsMOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293
ChainResidueDetails
ASER184
BSER184
CSER184

site_idSWS_FT_FI6
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN3
BASN3
CASN3

222036

PDB entries from 2024-07-03

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