3H6U

Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS1493 at 1.85 A resolution

Summary for 3H6U

Entry DOI	10.2210/pdb3h6u/pdb
Related	1LBC 3H6T 3H6V 3H6W
Descriptor	Glutamate receptor 2, GLUTAMIC ACID, (3S)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, ... (7 entities in total)
Functional Keywords	ampa receptor ligand-bidning core, iglur2 s1s2j-n754s, allosteric modulation, membrane protein
Biological source	Rattus norvegicus (rat) More
Cellular location	Cell membrane; Multi-pass membrane protein: P19491
Total number of polymer chains	1
Total formula weight	30720.02
Authors	Hald, H.,Gajhede, M.,Kastrup, J.S. (deposition date: 2009-04-24, release date: 2009-07-28, Last modification date: 2023-09-06)
Primary citation	Hald, H.,Ahring, P.K.,Timmermann, D.B.,Liljefors, T.,Gajhede, M.,Kastrup, J.S. Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2. J.Mol.Biol., 391:906-917, 2009 Cited by PubMed: 19591837 DOI: 10.1016/j.jmb.2009.07.002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation