3H6U
Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS1493 at 1.85 A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glutamate receptor 2 | polymer | 263 | 29194.7 | 1 | UniProt (P19491) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (rat) | GluR-2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, AMPA-selective glutamate receptor 2 |
| 2 | B (A) | GLUTAMIC ACID | non-polymer | 147.1 | 1 | Chemie (GLU) | |||
| 3 | C (A) | (3S)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide | non-polymer | 428.6 | 1 | Chemie (NS3) | |||
| 4 | D, E, F, G, H... (A) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 5 | J, K (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | L (A) | CITRATE ANION | non-polymer | 189.1 | 1 | Chemie (FLC) | |||
| 7 | M (A) | water | water | 18.0 | 384 | Chemie (HOH) |
Sequence modifications
A: 3 - 117 (UniProt: P19491)
A: 120 - 263 (UniProt: P19491)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Ala 2 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 118 | - | linker |
| Thr 119 | - | linker |
| Ser 242 | Asn 775 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 29194.7 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1525.4 | |
| All* | Total formula weight | 30720.0 |
