3H6U

Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS1493 at 1.85 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU A 264

Chain	Residue
A	TYR61
A	TYR220
A	HOH388
A	HOH438
A	HOH479
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	GLY141
A	SER142
A	THR143
A	GLU193

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE NS3 A 265

Chain	Residue
A	ILE92
A	PRO105
A	MET107
A	SER108
A	SER217
A	GLY219
A	SER242
A	ASP248
A	HOH410
A	HOH516
A	HOH548
A	HOH548
A	HOH637

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 266

Chain	Residue
A	ARG31
A	HIS46
A	LYS240
A	GLN244
A	GOL273
A	HOH525
A	HOH579
A	HOH581

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 267

Chain	Residue
A	ASP139
A	SER140
A	LYS144
A	ARG148
A	HOH411
A	HOH457
A	HOH593
A	HOH604

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 268

Chain	Residue
A	GLU27
A	GLY28
A	ASN29
A	GLU30
A	ARG149
A	FLC274
A	HOH349
A	HOH612

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 269

Chain	Residue
A	ASN22
A	LEU26
A	ARG64
A	LYS69
A	HOH526
A	HOH626
A	HOH647

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 270

Chain	Residue
A	LYS82
A	LYS116

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 271

Chain	Residue
A	SER194
A	GLU198
A	ASN214
A	HOH277
A	HOH508
A	HOH601

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 272

Chain	Residue
A	GLU33
A	TRP254
A	LYS258
A	HOH412

---

site_id	BC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 273

Chain	Residue
A	GLU42
A	LYS45
A	HIS46
A	LEU241
A	GLN244
A	SO4266
A	HOH525
A	HOH546
A	HOH631

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FLC A 274

Chain	Residue
A	ARG148
A	ARG149
A	TRP159
A	ARG163
A	SO4268

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---