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3H06

Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282

Summary for 3H06
Entry DOI10.2210/pdb3h06/pdb
Related3H03
DescriptorGlutamate receptor 2, 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid (3 entities in total)
Functional Keywordsglutamate receptor, glur2, ampa receptor, neurotransmitter receptor, s1s2, willardiine, membrane protein
Biological sourceRattus norvegicus
More
Cellular locationCell membrane; Multi-pass membrane protein: P19491
Total number of polymer chains8
Total formula weight233348.93
Authors
Ahmed, A.H.,Oswald, R.E. (deposition date: 2009-04-08, release date: 2009-05-05, Last modification date: 2017-08-23)
Primary citationAhmed, A.H.,Thompson, M.D.,Fenwick, M.K.,Romero, B.,Loh, A.P.,Jane, D.E.,Sondermann, H.,Oswald, R.E.
Mechanisms of antagonism of the GluR2 AMPA receptor: structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain.
Biochemistry, 48:3894-3903, 2009
Cited by
PubMed: 19284741
DOI: 10.1021/bi900107m
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

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