2ZY1

Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-830

Summary for 2ZY1

Entry DOI	10.2210/pdb2zy1/pdb
Related	2ZCO 2ZCP 2ZCQ 2ZCR 2ZCS
Descriptor	Dehydrosqualene synthase, dipotassium (2-oxo-2-{[3-(3-phenoxyphenyl)propyl]amino}ethyl)phosphonate (3 entities in total)
Functional Keywords	crtm, carotenoid biosynthesis, staphyloxanthin biosynthesis, transferase, head-to-head condensation, inhibitor
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	35213.00
Authors	Liu, C.I.,Jeng, W.Y.,Wang, A.H.J.,Oldfield, E. (deposition date: 2009-01-10, release date: 2009-09-01, Last modification date: 2023-11-01)
Primary citation	Song, Y.,Liu, C.I.,Lin, F.Y.,No, J.H.,Hensler, M.,Liu, Y.L.,Jeng, W.Y.,Low, J.,Liu, G.Y.,Nizet, V.,Wang, A.H.J.,Oldfield, E. Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results. J.Med.Chem., 52:3869-3880, 2009 Cited by PubMed: 19456099 DOI: 10.1021/jm9001764 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.78 Å)

Structure validation