2ZNO
Human PPAR gamma ligand binding domain in complex with a synthetic agonist TIPP703
Summary for 2ZNO
Entry DOI | 10.2210/pdb2zno/pdb |
Related | 2ZNN 2ZNP 2ZNQ |
Descriptor | Peroxisome proliferator-activated receptor gamma, (2S)-2-(4-propoxy-3-{[({4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}carbonyl)amino]methyl}benzyl)butanoic acid (3 entities in total) |
Functional Keywords | nuclear receptor, protein-ligand complex, ppar, activator, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, receptor, transcription, transcription regulation, zinc-finger |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P37231 |
Total number of polymer chains | 2 |
Total formula weight | 66068.65 |
Authors | Oyama, T.,Waku, T.,Kasuga, J.,Miyachi, H.,Morikawa, K. (deposition date: 2008-04-30, release date: 2009-05-05, Last modification date: 2023-11-01) |
Primary citation | Oyama, T.,Toyota, K.,Waku, T.,Hirakawa, Y.,Nagasawa, N.,Kasuga, J.,Hashimoto, Y.,Miyachi, H.,Morikawa, K. Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures Acta Crystallogr.,Sect.D, 65:786-795, 2009 Cited by PubMed: 19622862DOI: 10.1107/S0907444909015935 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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