2ZKF
Crystal structure of the SRA domain of mouse Np95 in complex with hemi-methylated CpG DNA
Summary for 2ZKF
Entry DOI | 10.2210/pdb2zkf/pdb |
Related | 2ZKD 2ZKE 2ZKG |
Descriptor | E3 ubiquitin-protein ligase UHRF1, DNA (5'-D(P*DCP*DAP*DCP*DCP*DGP*DGP*DAP*DTP*DAP*DGP*DA)-3'), DNA (5'-D(*DCP*DTP*DAP*DTP*DCP*(5CM)P*DGP*DGP*DTP*DGP*DA)-3'), ... (4 entities in total) |
Functional Keywords | protein-dna interaction, cell cycle, developmental protein, dna damage, dna repair, dna-binding, ligase, metal-binding, nucleus, phosphoprotein, transcription, transcription regulation, ubl conjugation pathway, zinc-finger |
Biological source | Mus musculus (Mouse) More |
Cellular location | Nucleus : Q8VDF2 |
Total number of polymer chains | 3 |
Total formula weight | 30137.56 |
Authors | Arita, K.,Ariyoshi, M.,Tochio, H.,Nakamura, Y.,Shirakawa, M. (deposition date: 2008-03-19, release date: 2008-09-09, Last modification date: 2023-11-01) |
Primary citation | Arita, K.,Ariyoshi, M.,Tochio, H.,Nakamura, Y.,Shirakawa, M. Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism Nature, 455:818-821, 2008 Cited by PubMed: 18772891DOI: 10.1038/nature07249 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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