2ZEU
S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with BPH-715
Summary for 2ZEU
Entry DOI | 10.2210/pdb2zeu/pdb |
Related | 2DH4 2E8T 2E8U 2E8V 2E8W 2E8X 2E90 2E91 2E92 2E93 2E94 2E95 2ZEV |
Descriptor | Geranylgeranyl pyrophosphate synthetase, 3-(DECYLOXY)-1-(2,2-DIPHOSPHONOETHYL)PYRIDINIUM (3 entities in total) |
Functional Keywords | prenyltransferase, farnesyl pyrophosphate, bisphosphonate, carotenoid biosynthesis, isoprene biosynthesis, multifunctional enzyme, protein transport, transport, transferase |
Biological source | Saccharomyces cerevisiae (Baker's yeast) |
Cellular location | Cytoplasm (By similarity): Q12051 |
Total number of polymer chains | 2 |
Total formula weight | 79446.89 |
Authors | Guo, R.T.,Chen, C.K.-M.,Cao, R.,Oldfield, E.,Wang, A.H.-J. (deposition date: 2007-12-17, release date: 2008-12-23, Last modification date: 2023-11-01) |
Primary citation | Zhang, Y.,Cao, R.,Yin, F.,Hudock, M.P.,Guo, R.T.,Krysiak, K.,Mukherjee, S.,Gao, Y.-G.,Robinson, H.,Song, Y.,No, J.H.,Bergan, K.,Leon, A.,Cass, L.,Goddard, A.,Chang, T.-K.,Lin, F.-Y.,Van Beek, E.,Papapoulos, S.,Wang, A.H.-J.,Kubo, T.,Ochi, M.,Mukkamala, D.,Oldfield, E. Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation J.Am.Chem.Soc., 131:5153-5162, 2009 Cited by PubMed: 19309137DOI: 10.1021/ja808285e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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