2ZEB

Potent, Nonpeptide Inhibitors of Human Mast Cell Tryptase

Summary for 2ZEB

Entry DOI	10.2210/pdb2zeb/pdb
Related	2ZEC
Descriptor	Tryptase beta 2, 1-(1'-{[3-(methylsulfanyl)-2-benzothiophen-1-yl]carbonyl}spiro[1-benzofuran-3,4'-piperidin]-5-yl)methanamine (3 entities in total)
Functional Keywords	tryptase, serine protease, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	110758.84
Authors	Spurlino, J.C.,Lewandowski, F.,Milligan, C. (deposition date: 2007-12-08, release date: 2008-12-09, Last modification date: 2011-07-13)
Primary citation	Costanzo, M.J.,Yabut, S.C.,Zhang, H.-C.,White, K.B.,de Garavilla, L.,Wang, Y.,Minor, L.K.,Tounge, B.A.,Barnakov, A.N.,Lewandowski, F.,Milligan, C.,Spurlino, J.C.,Abraham, W.M.,Boswell-Smith, V.,Page, C.P.,Maryanoff, B.E. Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives Bioorg.Med.Chem.Lett., 18:2114-2121, 2008 Cited by PubMed: 18272363 DOI: 10.1016/j.bmcl.2008.01.093 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation