2ZEB
Potent, Nonpeptide Inhibitors of Human Mast Cell Tryptase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006508 | biological_process | proteolysis |
| A | 0006952 | biological_process | defense response |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0022617 | biological_process | extracellular matrix disassembly |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0062023 | cellular_component | collagen-containing extracellular matrix |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006508 | biological_process | proteolysis |
| B | 0006952 | biological_process | defense response |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0022617 | biological_process | extracellular matrix disassembly |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0062023 | cellular_component | collagen-containing extracellular matrix |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005615 | cellular_component | extracellular space |
| C | 0006508 | biological_process | proteolysis |
| C | 0006952 | biological_process | defense response |
| C | 0008236 | molecular_function | serine-type peptidase activity |
| C | 0022617 | biological_process | extracellular matrix disassembly |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0062023 | cellular_component | collagen-containing extracellular matrix |
| D | 0004252 | molecular_function | serine-type endopeptidase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005615 | cellular_component | extracellular space |
| D | 0006508 | biological_process | proteolysis |
| D | 0006952 | biological_process | defense response |
| D | 0008236 | molecular_function | serine-type peptidase activity |
| D | 0022617 | biological_process | extracellular matrix disassembly |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0062023 | cellular_component | collagen-containing extracellular matrix |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 11M A 244 |
| Chain | Residue |
| A | GLN87 |
| A | GLY217 |
| A | GLY225 |
| C | TYR84 |
| A | ASP188 |
| A | SER189 |
| A | CYS190 |
| A | GLN191 |
| A | SER194 |
| A | TRP214 |
| A | GLY215 |
| A | GLU216 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 11M B 244 |
| Chain | Residue |
| B | GLN87 |
| B | ASP188 |
| B | SER189 |
| B | CYS190 |
| B | GLN191 |
| B | SER194 |
| B | TRP214 |
| B | GLY215 |
| B | GLU216 |
| B | GLY217 |
| B | GLY225 |
| B | HOH290 |
| B | HOH297 |
| D | TYR84 |
| D | THR85 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 11M D 244 |
| Chain | Residue |
| B | TYR84 |
| B | THR85 |
| D | GLN87 |
| D | ASP188 |
| D | SER189 |
| D | CYS190 |
| D | GLN191 |
| D | TRP214 |
| D | GLY215 |
| D | GLU216 |
| D | GLY217 |
| D | HOH302 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 11M C 244 |
| Chain | Residue |
| A | TYR84 |
| A | THR85 |
| C | GLN87 |
| C | ASP188 |
| C | SER189 |
| C | CYS190 |
| C | GLN191 |
| C | SER194 |
| C | TRP214 |
| C | GLY215 |
| C | GLU216 |
| C | GLY217 |
| C | HOH303 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | ACT_SITE: Charge relay system |
| Chain | Residue | Details |
| A | HIS44 | |
| D | HIS44 | |
| D | ASP91 | |
| D | SER194 | |
| A | ASP91 | |
| A | SER194 | |
| B | HIS44 | |
| B | ASP91 | |
| B | SER194 | |
| C | HIS44 | |
| C | ASP91 | |
| C | SER194 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | LYS102 | |
| B | LYS102 | |
| C | LYS102 | |
| D | LYS102 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| A | ASN203 | |
| B | ASN203 | |
| C | ASN203 | |
| D | ASN203 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | HIS44 | |
| A | ASP91 | |
| A | SER194 |
| site_id | CSA10 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | HIS44 | |
| B | ASP91 |
| site_id | CSA11 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| C | HIS44 | |
| C | ASP91 |
| site_id | CSA12 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| D | HIS44 | |
| D | ASP91 |
| site_id | CSA13 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | GLY192 | |
| A | SER194 |
| site_id | CSA14 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | GLY192 | |
| B | SER194 |
| site_id | CSA15 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| C | GLY192 | |
| C | SER194 |
| site_id | CSA16 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| D | GLY192 | |
| D | SER194 |
| site_id | CSA17 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | GLY195 | |
| A | SER194 |
| site_id | CSA18 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | GLY195 | |
| B | SER194 |
| site_id | CSA19 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| C | GLY195 | |
| C | SER194 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | HIS44 | |
| B | ASP91 | |
| B | SER194 |
| site_id | CSA20 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| D | GLY195 | |
| D | SER194 |
| site_id | CSA21 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | GLY192 | |
| A | HIS44 | |
| A | ASP91 | |
| A | SER194 |
| site_id | CSA22 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | GLY192 | |
| B | HIS44 | |
| B | ASP91 | |
| B | SER194 |
| site_id | CSA23 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| C | GLY192 | |
| C | HIS44 | |
| C | ASP91 | |
| C | SER194 |
| site_id | CSA24 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| D | GLY192 | |
| D | HIS44 | |
| D | ASP91 | |
| D | SER194 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| C | HIS44 | |
| C | ASP91 | |
| C | SER194 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| D | HIS44 | |
| D | ASP91 | |
| D | SER194 |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | HIS44 | |
| A | GLY195 | |
| A | ASP91 | |
| A | SER194 |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | HIS44 | |
| B | GLY195 | |
| B | ASP91 | |
| B | SER194 |
| site_id | CSA7 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| C | HIS44 | |
| C | GLY195 | |
| C | ASP91 | |
| C | SER194 |
| site_id | CSA8 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| D | HIS44 | |
| D | GLY195 | |
| D | ASP91 | |
| D | SER194 |
| site_id | CSA9 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | HIS44 | |
| A | ASP91 |
