2ZC5

Penicillin-binding protein 1A (PBP 1A) acyl-enzyme complex (biapenem) from Streptococcus pneumoniae

2ZC5 の概要

• エントリーDOI: 10.2210/pdb2zc5/pdb
• 関連するPDBエントリー: 2ZC3 2ZC4 2ZC6
• 分子名称: Penicillin-binding protein 1A, ZINC ION, (4R,5S)-3-(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium-6-ylsulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-meth yl-4,5-dihydro-1H-pyrrole-2-carboxylate, ... (5 entities in total)
• 機能のキーワード: peptidoglycan synthesis, cell wall, penicillin-binding, antibiotics, biapenem, antibiotic resistance, cell shape, cell wall biogenesis/degradation, multifunctional enzyme, secreted, biosynthetic protein
• 由来する生物種: Streptococcus pneumoniae; 詳細
• 細胞内の位置: Secreted: Q8DR59
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 93639.87

構造登録者

Yamada, M.,Watanabe, T.,Takeuchi, Y. (登録日: 2007-11-02, 公開日: 2008-04-08, 最終更新日: 2023-11-01)

• 主引用文献: Yamada, M.,Watanabe, T.,Baba, N.,Takeuchi, Y.,Ohsawa, F.,Gomi, S.; Crystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniae; Antimicrob.Agents Chemother., 52:2053-2060, 2008; PubMed: 18391040; DOI: 10.1128/AAC.01456-07

実験手法

X-RAY DIFFRACTION (3 Å)