2Z1W

tRNA guanine transglycosylase TGT E235Q mutant in complex with BDI (2-BUTYL-5,6-DIHYDRO-1H-IMIDAZO[4,5-D]PYRIDAZINE-4,7-DIONE)

Summary for 2Z1W

• Entry DOI: 10.2210/pdb2z1w/pdb
• Related: 1P0B 2OKO 2Z1V 2Z1X
• Descriptor: Queuine tRNA-ribosyltransferase, ZINC ION, 2-BUTYL-5,6-DIHYDRO-1H-IMIDAZO[4,5-D]PYRIDAZINE-4,7-DIONE, ... (5 entities in total)
• Functional Keywords: tgt, e235q mutant, bdi, bih, 2-butyl-5, 6-dihydro-1h-imidazo[4, 5-d]pyridazine-4, 7-dione, transferase
• Biological source: Zymomonas mobilis
• Total number of polymer chains: 1
• Total formula weight: 44027.19

Authors

Tidten, N.,Stengl, B.,Heine, A.,Garcia, G.A.,Klebe, G.,Reuter, K. (deposition date: 2007-05-16, release date: 2007-11-06, Last modification date: 2023-11-01)

• Primary citation: Tidten, N.,Stengl, B.,Heine, A.,Garcia, G.A.,Klebe, G.,Reuter, K.; Glutamate versus Glutamine Exchange Swaps Substrate Selectivity in tRNA-Guanine Transglycosylase: Insight into the Regulation of Substrate Selectivity by Kinetic and Crystallographic Studies; J.Mol.Biol., 374:764-776, 2007; PubMed: 17949745; DOI: 10.1016/j.jmb.2007.09.062

Experimental method

X-RAY DIFFRACTION (1.63 Å)