2YB9

Crystal Structure of Human Neutral Endopeptidase complexed with a heteroarylalanine diacid.

Summary for 2YB9

Entry DOI	10.2210/pdb2yb9/pdb
Related	1DL9 1DMT 1QVD 1R1H 1R1I 1R1J 1Y8J
Descriptor	NEPRILYSIN, ZINC ION, HETEROARYLALANINE 5-PHENYL OXAZOLE, ... (4 entities in total)
Functional Keywords	hydrolase, neprilysine, metalloproteinase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cell membrane; Single-pass type II membrane protein: P08473
Total number of polymer chains	1
Total formula weight	80033.42
Authors	Glossop, M.S.,Bazin, R.J.,Dack, K.N.,Done, S.,Fox, D.N.A.,MacDonald, G.A.,Mills, M.,Owen, D.R.,Phillips, C.,Reeves, K.A.,Ringer, T.J.,Strang, R.S.,Watson, C.A.L. (deposition date: 2011-03-02, release date: 2011-05-25, Last modification date: 2011-11-02)
Primary citation	Glossop, M.S.,Bazin, R.J.,Dack, K.N.,Fox, D.N.A.,Macdonald, G.A.,Mills, M.,Owen, D.R.,Phillips, C.,Reeves, K.A.,Ringer, T.J.,Strang, R.S.,Watson, C.A.L. Synthesis and Evaluation of Heteroarylalanine Diacids as Potent and Selective Neutral Endopeptidase Inhibitors. Bioorg.Med.Chem.Lett., 21:3404-, 2011 Cited by PubMed: 21515054 DOI: 10.1016/J.BMCL.2011.03.109 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation