1Y8J
Crystal Structure of human NEP complexed with an imidazo[4,5-c]pyridine inhibitor
Summary for 1Y8J
Entry DOI | 10.2210/pdb1y8j/pdb |
Related | 1DMT 1R1H 1R1I 1R1J |
Descriptor | Neprilysin, 2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (6 entities in total) |
Functional Keywords | lt1_6, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type II membrane protein: P08473 |
Total number of polymer chains | 1 |
Total formula weight | 80583.96 |
Authors | Sahli, S.,Frank, B.,Schweizer, W.B.,Diederich, F.,Blum-Kaelin, D.,Aebi, J.D.,Bohm, H.J.,Oefner, C.,Dale, G.E. (deposition date: 2004-12-13, release date: 2005-06-07, Last modification date: 2023-08-23) |
Primary citation | Sahli, S.,Frank, B.,Schweizer, W.B.,Diederich, F.,Blum-Kaelin, D.,Aebi, J.D.,Bohm, H.J.,Oefner, C.,Dale, G.E. Second-Generation Inhibitors for the Metalloprotease Neprilysin Based on Bicyclic Heteroaromatic Scaffolds: Synthesis, Biological Activity, and X-ray Crystal Structure Analysis HELV.CHIM.ACTA, 88:731-750, 2005 Cited by DOI: 10.1002/hlca.200590051PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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