2YB9
Crystal Structure of Human Neutral Endopeptidase complexed with a heteroarylalanine diacid.
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001786 | molecular_function | phosphatidylserine binding |
A | 0001822 | biological_process | kidney development |
A | 0001890 | biological_process | placenta development |
A | 0004175 | molecular_function | endopeptidase activity |
A | 0004222 | molecular_function | metalloendopeptidase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005769 | cellular_component | early endosome |
A | 0005802 | cellular_component | trans-Golgi network |
A | 0005886 | cellular_component | plasma membrane |
A | 0005903 | cellular_component | brush border |
A | 0005925 | cellular_component | focal adhesion |
A | 0006508 | biological_process | proteolysis |
A | 0006518 | biological_process | peptide metabolic process |
A | 0007611 | biological_process | learning or memory |
A | 0008021 | cellular_component | synaptic vesicle |
A | 0008233 | molecular_function | peptidase activity |
A | 0008237 | molecular_function | metallopeptidase activity |
A | 0008238 | molecular_function | exopeptidase activity |
A | 0008270 | molecular_function | zinc ion binding |
A | 0009986 | cellular_component | cell surface |
A | 0010814 | biological_process | substance P catabolic process |
A | 0010815 | biological_process | bradykinin catabolic process |
A | 0016020 | cellular_component | membrane |
A | 0016485 | biological_process | protein processing |
A | 0019233 | biological_process | sensory perception of pain |
A | 0030163 | biological_process | protein catabolic process |
A | 0030324 | biological_process | lung development |
A | 0030424 | cellular_component | axon |
A | 0030425 | cellular_component | dendrite |
A | 0030667 | cellular_component | secretory granule membrane |
A | 0031410 | cellular_component | cytoplasmic vesicle |
A | 0042277 | molecular_function | peptide binding |
A | 0042447 | biological_process | hormone catabolic process |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0043025 | cellular_component | neuronal cell body |
A | 0043627 | biological_process | response to estrogen |
A | 0044306 | cellular_component | neuron projection terminus |
A | 0045121 | cellular_component | membrane raft |
A | 0045202 | cellular_component | synapse |
A | 0046449 | biological_process | creatinine metabolic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0050435 | biological_process | amyloid-beta metabolic process |
A | 0050769 | biological_process | positive regulation of neurogenesis |
A | 0061837 | biological_process | neuropeptide processing |
A | 0070012 | molecular_function | oligopeptidase activity |
A | 0070062 | cellular_component | extracellular exosome |
A | 0071345 | biological_process | cellular response to cytokine stimulus |
A | 0071492 | biological_process | cellular response to UV-A |
A | 0071493 | biological_process | cellular response to UV-B |
A | 0090399 | biological_process | replicative senescence |
A | 0097242 | biological_process | amyloid-beta clearance |
A | 0098793 | cellular_component | presynapse |
A | 0150094 | biological_process | amyloid-beta clearance by cellular catabolic process |
A | 1900273 | biological_process | positive regulation of long-term synaptic potentiation |
A | 1901612 | molecular_function | cardiolipin binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN A 1750 |
Chain | Residue |
A | HIS583 |
A | HIS587 |
A | GLU646 |
A | HIS711 |
A | HA01751 |
site_id | AC2 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE HA0 A 1751 |
Chain | Residue |
A | ASN542 |
A | ALA543 |
A | HIS583 |
A | GLU584 |
A | HIS587 |
A | GLU646 |
A | TRP693 |
A | GLY695 |
A | TYR697 |
A | HIS711 |
A | GLY714 |
A | ARG717 |
A | ZN1750 |
A | HOH2053 |
A | HOH2482 |
A | ARG102 |
A | PHE106 |
A | ASP107 |
A | ARG110 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VIGHEITHGF |
Chain | Residue | Details |
A | VAL580-PHE589 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01233, ECO:0000255|PROSITE-ProRule:PRU10095 |
Chain | Residue | Details |
A | GLU584 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU01233, ECO:0000269|PubMed:8168535 |
Chain | Residue | Details |
A | ASP650 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P07861 |
Chain | Residue | Details |
A | ARG102 |
site_id | SWS_FT_FI4 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01233 |
Chain | Residue | Details |
A | HIS583 | |
A | HIS587 | |
A | GLU646 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10669592, ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:14747736, ECO:0000269|PubMed:17704566 |
Chain | Residue | Details |
A | ASN144 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519 |
Chain | Residue | Details |
A | ASN284 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10669592, ECO:0000269|PubMed:14747736, ECO:0000269|PubMed:17704566 |
Chain | Residue | Details |
A | ASN324 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10669592, ECO:0000269|PubMed:14747736, ECO:0000269|PubMed:17704566, ECO:0000269|PubMed:22766194 |
Chain | Residue | Details |
A | ASN627 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 7 |
Details | M-CSA 623 |
Chain | Residue | Details |
A | HIS583 | metal ligand |
A | GLU584 | proton shuttle (general acid/base) |
A | HIS587 | metal ligand |
A | GLU646 | metal ligand |
A | ASP650 | electrostatic stabiliser |
A | HIS711 | electrostatic stabiliser |
A | ARG717 | electrostatic stabiliser |