2YAU

X-ray structure of the Leishmania infantum tryopanothione reductase in complex with auranofin

Summary for 2YAU

Entry DOI	10.2210/pdb2yau/pdb
Related	2JK6 2W0H 2X50
Descriptor	TRYPANOTHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (7 entities in total)
Functional Keywords	oxidoreductase
Biological source	LEISHMANIA INFANTUM
Total number of polymer chains	2
Total formula weight	114962.74
Authors	Baiocco, P.,Ilari, A.,Colotti, G. (deposition date: 2011-02-24, release date: 2012-01-11, Last modification date: 2023-12-20)
Primary citation	Ilari, A.,Baiocco, P.,Messori, L.,Fiorillo, A.,Boffi, A.,Gramiccia, M.,Di Muccio, T.,Colotti, G. A Gold-Containing Drug Against Parasitic Polyamine Metabolism: The X-Ray Structure of Trypanothione Reductase from Leishmania Infantum in Complex with Auranofin Reveals a Dual Mechanism of Enzyme Inhibition. Amino Acids, 42:803-, 2012 Cited by PubMed: 21833767 DOI: 10.1007/S00726-011-0997-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation