2YAU
X-ray structure of the Leishmania infantum tryopanothione reductase in complex with auranofin
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | TRYPANOTHIONE REDUCTASE | polymer | 511 | 55257.5 | 2 | UniProt (A4HSF7) Pfam (PF07992) Pfam (PF02852) In PDB | LEISHMANIA INFANTUM | |
2 | A, B | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 2 | Chemie (FAD) | |||
3 | A, B | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
4 | A, B | GOLD ION | non-polymer | 197.0 | 2 | Chemie (AU) | |||
5 | A, B | 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranose | non-polymer | 364.4 | 2 | Chemie (TS8) | |||
6 | A, B | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
7 | A, B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) |
Sequence modifications
A, B: 1 - 491 (UniProt: A4HSF7)
PDB | External Database | Details |
---|---|---|
Met -19 | - | expression tag |
Gly -18 | - | expression tag |
Ser -17 | - | expression tag |
Ser -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
Ser -9 | - | expression tag |
Ser -8 | - | expression tag |
Gly -7 | - | expression tag |
Leu -6 | - | expression tag |
Val -5 | - | expression tag |
Pro -4 | - | expression tag |
Arg -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 110515.1 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 4447.6 | |
All* | Total formula weight | 114962.7 |