2W0H

X ray structure of Leishmania infantum Trypanothione reductase in complex with antimony and NADPH

Summary for 2W0H

Related2JK6
DescriptorTRYPANOTHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, ANTIMONY (III) ION, ... (6 entities in total)
Functional Keywordsfad, leishamnia, antimonials, flavoprotein, reduced nadph, oxidoreductase, redox-active center, trypanothione metabolism
Biological sourceLEISHMANIA INFANTUM
Total number of polymer chains2
Total molecular weight114012.68
Authors
Baiocco, P.,Colotti, G.,Franceschini, S.,Ilari, A. (deposition date: 2008-08-18, release date: 2009-04-28, Last modification date: 2011-07-13)
Primary citation
Baiocco, P.,Colotti, G.,Franceschini, S.,Ilari, A.
Molecular Basis of Antimony Treatment in Leishmaniasis.
J.Med.Chem., 52:2603-, 2009
PubMed: 19317451 (PDB entries with the same primary citation)
DOI: 10.1021/JM900185Q
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.26770.2%5.8%0.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload