2XYX

Novel Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (PPAR) gamma-delta Agonists with High Potency and In-vivo Efficacy

2XYX の概要

• エントリーDOI: 10.2210/pdb2xyx/pdb
• 関連するPDBエントリー: 1GWX 1Y0S 2AWH 2B50 2BAW 2GWX 2J14 2XYJ 2XYW 3GWX
• 分子名称: PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA, 4-[2-[[3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDIN-2-YL]AMINO]ETHYL]-N-(5-PROPAN-2-YL-1,3,4-THIADIAZOL-2-YL)BENZENESULFONAMIDE, octyl beta-D-glucopyranoside, ... (4 entities in total)
• 機能のキーワード: dna-binding, transcription, transcription regulation, receptor, activator, zinc-finger
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 67589.16

構造登録者

Marquette, J.-P.,Mathieu, M. (登録日: 2010-11-19, 公開日: 2011-02-23, 最終更新日: 2024-05-01)

• 主引用文献: Keil, S.,Matter, H.,Schonafinger, K.,Glien, M.,Mathieu, M.,Marquette, J.-P.,Michot, N.,Haag-Diergarten, S.,Urmann, M.,Wendler, W.; Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (Ppar) Gamma / Delta Agonists with High Potency and in-Vivo Efficacy; Chemmedchem, 6:633-, 2011; PubMed: 21400663; DOI: 10.1002/CMDC.201100047

実験手法

X-RAY DIFFRACTION (2.7 Å)