2XYQ

Crystal structure of the nsp16 nsp10 SARS coronavirus complex

Summary for 2XYQ

Related2AHM 2D2D 1P9T 2XYV 1UK3 2XYR 1WOF 2AMD 2A5I 2V6N 2BX4 2ACF 1UK4 1Z1I 1O5S 2A5K 2C3S 1SXF 1UJ1 1UK2 2AMQ 2BX3 1PA5 1PUK 1UW7 1P76 1Q1X 2A5A 1YSY 1Z1J
DescriptorPUTATIVE 2'-O-METHYL TRANSFERASE, NON-STRUCTURAL PROTEIN 10, CHLORIDE ION, ... (8 entities in total)
Functional Keywordstransferase-viral protein complex, rossmann fold, transferase/viral protein
Biological sourceSARS CORONAVIRUS
Cellular locationPapain-like proteinase: Host membrane; Multi-pass membrane protein. Non-structural protein 4: Host membrane; Multi-pass membrane protein. Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region . Helicase: Host endoplasmic reticulum-Golgi intermediate compartment . Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region  P0C6X7 P0C6X7
Total number of polymer chains2
Total molecular weight46400.89
Authors
Decroly, E.,Debarnot, C.,Ferron, F.,Bouvet, M.,Coutard, B.,Imbert, I.,Gluais, L.,Papageorgiou, N.,Ortiz-Lombardia, M.,Lescar, J.,Canard, B. (deposition date: 2010-11-18, release date: 2011-10-19, Last modification date: 2018-01-24)
Primary citation
Decroly, E.,Debarnot, C.,Ferron, F.,Bouvet, M.,Coutard, B.,Imbert, I.,Gluais, L.,Papageorgiou, N.,Sharff, A.,Bricogne, G.,Ortiz-Lombardia, M.,Lescar, J.,Canard, B.
Crystal Structure and Functional Analysis of the Sars-Coronavirus RNA CAP 2'-O-Methyltransferase Nsp10/Nsp16 Complex.
Plos Pathog., 7:2059-, 2011
PubMed: 21637813 (PDB entries with the same primary citation)
DOI: 10.1371/JOURNAL.PPAT.1002059
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22821.0%1.5%8.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution